摘要
糖尿病(DM)是以高血糖为特征的一种慢性代谢性疾病,其主要并发症如糖尿病血管病变现已严重影响患者的生活质量,成为患者致死、致残的重要原因。糖尿病血管病变基础的病理变化为大血管病变和微血管病变:大血管病变主要累及胸主动脉、冠状动脉、颈动脉、脑动脉和周围血管等大血管,临床常见疾病是冠心病、脑卒中、周围神经性病变、下肢动脉硬化等;微血管病变主要累及心、脑、肾等微血管。现今社会各种新型口服降糖药和胰岛素在临床不断涌现,并广泛应用于临床。但中医药疗效稳定,副作用小,并可改善糖代谢、改善脂质代谢、改善胰岛素抵抗、改善氧化应激、改善炎症因子表达、改善血管内皮损伤、改善微循环障碍、改善纤溶系统和凝血系统平衡、改善中医证候等,在防治糖尿病血管病变等方面也得到大家广泛认可和应用。中医学对糖尿病血管病变病因、病机、治法也有深刻的理解和认识,因此本文就中医学对糖尿病血管病变的认识及近3年来采用益气活血方治疗糖尿病血管病变的作用机制综述如下。
Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia. Its main complications of diabetes,such as diabetic angiopathy,have seriously affected the quality of life for patients,and have become an important cause of death and disability. The underlying pathological changes include macrovascular lesions and microvascular lesions. Diabetic macrovascular lesions mainly involve thoracic aorta,coronary artery,carotid artery,cerebral artery and peripheral blood vessels,etc.,and the common clinical diseases include coronary heart disease,stroke,peripheral neuropathy,lower extremity arteriosclerosis,etc.Diabetic microvascular lesions mainly involve the heart,brain,kidney and other microvessels. Nowadays,various new oral hypoglycemic agents and insulin have emerged in the society and are widely used in clinical practice.However,traditional Chinese medicines (TCMs) have stable curative effect,less side effect,and can improve glucose metabolism,lipid metabolism,insulin resistance,oxidative stress,expression of inflammatory cytokines,vascular endothelial injury,microcirculation disorders,balance of fibrinolysis system and blood coagulation system,and improve the syndromes of TCMs,etc. They have been widely recognized and applied in the prevention and treatment of diabetic angiopathy. A profound understanding on the etiology,pathogenesis and treatment of diabetic angiopathy has been formed in Chinese medicine. Therefore,in this paper,we would summarizes the understanding on Chinese medicine for diabetic angiopathy and the mechanism of Yiqi Huoxue prescription in the treatment of diabetic angiopathy in the past three years.
作者
胡艳红
杨静
修成奎
王雪
方靖漪
王佳丽
刘奕清
刘逸南
雷燕
HU Yan-hong;YANG Jing;XIU Cheng-kui;WANG Xue;FANG Jing-yi;WANG Jia-li;LIU Yi-qing;LIU Yi-nan;LEI Yan(China Academy of Traditional Chinese Medicine(TCM)Medical Experimental Center,Beijing Key Laboratory of Basic Research on Prevention and Treatment of Major Diseases by TCM,Beijing 100700,China;Chinese Medicine Research Institute of Guangdong Pharmaceutical University,Guangdong Research Center for Integrative Medicine in Metabolic Diseases,Guangzhou 510006,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第8期1-12,共12页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81673822)
中国中医科学院自主选题项目(ZZ2018014,ZZ2017011)
北京市自然科学基金项目(7182120)。
关键词
益气活血方
糖尿病血管病变
当归补血汤
丹蛭降糖胶囊
益气活血通络汤
气虚血瘀
Yiqi Huoxue prescription
diabetic angiopathy
Danggui Buxue decoction
Danqi Jiangtang capsule
Yiqi Huoxue Tongluo decoction
Qi deficiency and blood stasis
作者简介
第一作者:胡艳红,在读博士,从事中西医结合心血管病研究,E-mail:huyanhong3737@163.com;通信作者:雷燕,首席研究员,博士生导师,从事中西医结合心血管病研究,E-mail:13651217893@163.com。
