摘要
目的研究马鹿茸组合物抗体力疲劳的作用及其机制。方法 NIH小鼠和SD大鼠随机分为空白对照组、奕华胶囊组(600 mg/kg)、马鹿茸组合物低、中、高剂量组(135、270、810 mg/kg),各组动物分别灌胃给予相应溶液,每天1次,连续30 d。末次灌胃30 min后检测各组动物的负重游泳时长、肝糖原含量及游泳后血清尿素氮、血乳酸浓度。结果与阴性对照组比较,马鹿茸组合物组动物的游泳时长增加(P<0. 05)、肝糖原含量升高(P<0. 05)、血乳酸曲线下面积降低(P<0. 05)。结论马鹿茸组合物具有抗体力疲劳作用,其机制可能与增加机体肝糖原储备和降低运动所引起的血乳酸堆积有关。
Objective To investigate the anti-fatigue effect of hairy antler composition and its mechanism.Methods NIH mice and SD rats were randomly divided into a blank control group,Yihua capsule group( 600 mg/kg),and three dosage groups of hairy antler composition( 135,270,and 810 mg/kg). The Yihua capsule,hairy antler composition,at various concentrations or water were administered orally to the corresponding groups once a day for 30 days.Serum BUN and blood lactic acid after swimming,loaded swimming time,and hepatic glycogen content were measured at30 min after the last administration. Results The hairy antler composition significantly increased the loaded swimming time and the hepatic glycogen content in mice( P<0. 05) and decreased blood lactic acid( P<0. 05). Conclusions The hairy antler composition has an anti-fatigue effect.
作者
梁志健
陈桂煌
龙淑娴
黎丽斯
黎耀俊
白建瑜
饶子亮
LIANG Zhijian;CHEN Guihuang;LONG Shuxian;LI Lisi;LI Yaojun;BAI Jianyu;RAO Ziliang(Guangdong Medical Laboratory Animal Center,Foshan 528248,China)
出处
《中国比较医学杂志》
CAS
北大核心
2020年第3期39-43,共5页
Chinese Journal of Comparative Medicine
基金
广东省医学科研基金(A2018214、B2019154)
广东省科技计划项目(2016A030303027)。
关键词
马鹿茸
抗疲劳
负重游泳
乳酸
尿素氮
肝糖原
hairy antler
anti-fatigue
loaded swimming
lactic acid
BUN
hepatic glycogen
作者简介
梁志健(1989—),男,主管中药师,研究方向:药理与毒理学。E-mail:kenjiliang@foxmail.com;通信作者:饶子亮,(1983—),男,副主任药师,研究方向:药效评价。E-mail:343806059@qq.com。
