摘要
目的观察益气养阴解毒法治疗表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)相关皮疹的临床疗效;方法2016年1月—2019年9月于北京中医药大学东直门医院26例经病理确诊为肺腺癌,接受EGFR-TKIs治疗后出现皮疹的患者为治疗组;2016年1月—2019年9月于北京市东城区第一人民医院21例经病理确诊为肺腺癌,接受EGFR-TKIs治疗后出现皮疹的患者为对照组。治疗组予益气养阴解毒方口服,同时皮损部位应用本方外洗;治疗组皮损处外用百多邦莫匹罗星软膏。两组均以21 d为1个疗程,1个疗程后评价疗效。根据美国国家癌症研究所一不良事件公共术语标准4.0版(NCI-CTCAE 4.0)对皮肤毒性评级进行疗效评价;参考《中药新药临床研究指导原则》评价中医证候疗效;皮肤病生活质量指数(dermatology life quality index,DLQI)评价皮疹对患者生活质量的影响。结果一个疗程后,对照组及治疗组治疗前后比较,均出现不同程度改善,差异有统计学意义(P<0.05);治疗组优于对照组,差异有统计学意义(P<0.01);治疗组在中医证侯改善及生活质量方面优于对照组,差异有统计学意义(P<0.05)。结论益气养阴解毒方口服联合外洗对肺腺癌患者接受EGFR-TKIs治疗后出现的皮疹具有较好疗效,能减轻EGFR-TKIs引起的皮肤毒副反应。
Objective To observe the clinical efficacy of Yiqi Yangyin Jiedu Decoction in treating rash associated with epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs).Methods A total of 26 patients were included in the treatment group who were diagnosed as lung adenocarcinoma confirmed by pathology in Dongzhimen Hospital from January,2016 to September,2019 and received EGFR-TKIs treatment.A total of 21 patients were included in the control group who were diagnosed as lung adenocarcinoma confirmed by pathology in the First People's Hospital of Dongcheng District of Beijing from January,2016 to September,2019 and received EGFR-TKIs treatment.The treatment group was given Yiqi Yangyin Jiedu Formula orally and externally on the skin lesions.The control group was given Baiduobang Mupirocin Ointment externally on the skin lesions.Both groups were treated for 21 days as one course and the efficacy was evaluated after one course treatment.The clinical effect was evaluated by dermal toxicity grade according to National Cancer Institute-Common Terminology Criteria for Adverse Events Version 4.0(NCI-CTCAE 4.0).The clinical effect of TCM syndrome was evaluated according to the Guiding Principle for New Drug Clinical Research of TCM New Drug.Dermatology Life Quality Index(DLQI)was used to evaluate the quality of life in rash patients.Results After one treatment course,improvement was shown in both groups in different degrees,with statistical significance(P<0.05);and the effect in the treatment group was better than in the control group,with statistical significance(P<0.01).In terms of TCM syndrome and quality of life,the treatment group was better than the control group,with statistical significance(P<0.05).Conclusion Internal and external application of Yiqi Yangyin Jiedu Formula has a good clinical effect on treating rash in patients with lung adenocarcinoma after EGFR-TKIs treatment and it can reduce skin toxicity caused by EGFR-TKIs.
作者
关雅素
刘洋
吕鹏
GUAN Ya-su;LIU Yang;LYV Peng(The First People's Hospital of Dongcheng District of Beijing,Beijing 100075;Eye Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100040;Beijing University of Chinese Medicine,Beijing 100029)
出处
《世界中西医结合杂志》
2020年第3期528-531,共4页
World Journal of Integrated Traditional and Western Medicine
作者简介
通讯作者:吕鹏,Email:lvpeng514@126.com。
