摘要
目的:观察养阴清热解毒法治疗表皮生长因子受体络氨酸激酶抑制剂(EGFR-TKIs)相关皮疹的临床疗效。方法:41例经病理确诊为晚期肺腺癌,接受表皮生长因子受体酪氨酸激酶抑制剂治疗后出现皮疹的患者,分为治疗组21例,对照组20例。治疗组同时采用养阴清热解毒法治疗,每日口服汤药早晚两次;对照组同时采用百多邦莫匹罗星软膏外用。10 d为1个疗程,两组均连续用药2个疗程,根据National Cancer Institute-Common Terminology Criteria for Adverse Events Version 4.0(NCI-CTCAE4.0)对皮肤毒性评级,进行疗效评价。结果:治疗组治疗前后皮疹分级差异有统计学意义(P<0.05),治疗后两组比较皮疹分级差异有统计学意义(P<0.05)。治疗组总有效率为90%较对照组的总有效率30%差异有统计学意义(P<0.05)。结论:养阴清热解毒法能够减轻表皮生长因子受体酪氨酸激酶抑制剂引起的皮肤毒副反应。
Objective： To observe the effect of Yangyin Qingre Jiedu Principle（ YYQRJDP） treating rash related to epithelial growth factor receptor- tyrosine kinase inhibitors. Methods： Forty- one consecutive patients（ YYQRJDP group,n = 21; Bactroban group,n = 20） pathologically diagnosed as advanced lung adenocarcinoma,appearing rash related to Epithelial growth factor receptor- tyrosine kinase inhibitors treatment and traditional Chinese medicine（ TCM） syndrome of Yin deficiency and inner heat were enrolled. Patients were strictly controlled/surveyed during the entire 2- month treatment period and skin side effects by National Cancer Institute- Common Terminology Criteria for Adverse Events Version 4. 0（ NCI- CTCAE4. 0） were compared before and after two treatment cycles. Results： Rash degree in the YYQRJDP group had significant difference after comparing to those before treatment（ P 0. 05）. The rash improved significantly in the YYQRJEP group compared with the Bactroban group＇s after treatment（ P 0. 05）. The cured ＋ effective rates were 90% in the YYQRJDP group versus 30% in the Bactroban group（ P 0. 05）. Conclusion： Yangyin Qingre Jiedu Principle can reduce side effects of epithelial growth factor receptor- tyrosine kinase inhibitors to skin.
出处
《辽宁中医杂志》
CAS
北大核心
2016年第5期1005-1007,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
上海市科委课题(13ZR1442300)
关键词
表皮生长因子受体酪氨酸激酶抑制剂
皮疹
肺腺癌
养阴清热解毒法
epithelial growth factor receptor-tyrosine kinase inhibitors
rash
lung adenocarcinoma
Yangyin Qingre Jiedu Principle
作者简介
郭慧茹（1981-），女，辽宁丹东人，主治医师，博士，研究方向：中医药防治恶性肿瘤。
通讯作者：孙建立（1966-），男，河北保定人，主任医师，硕士研究生导师，博士，研究方向：中医药防治肿瘤的临床和实验研究，E—mail：1721679167@qq．com。
