摘要
目的探讨大剂量静脉滴注免疫球蛋白治疗系统性红斑狼疮的疗效。方法选取2015年12月~2018年12月在我院收治的系统性红斑狼疮患者100例,将其随机分为对照组与观察组,每组50例,对照组采用环磷酰胺静脉滴注、强的松口服、甲基强的松龙冲击治疗。观察组在对照组治疗的基础上,使用大剂量静脉滴注免疫球蛋白治疗。比较两组患者的治疗效果。结果观察组患者血小板达高峰平均时间,明显短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者系统性红斑狼疮疾病活动度评分(SLEDAI)、系统性红斑狼疮生活质量量表(SLEQOL)评分比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的SLE-QOL评分、SLEDAI评分明显低于对照组,差异有统计学意义(P<0.05)。观察组患者4周内血小板上50%以上的为100%,明显高于对照组的76%,差异有统计学意义(P<0.05)。两组不良反应发生情况比较无明显差异(P>0.05)。结论大剂量静脉滴注免疫球蛋白对系统性红斑狼疮的治疗有积极的作用,能够控制疾病活动度,提高患者的生活质量,不会增加不良反应。
Objective To investigate the efficacy of large dose intravenous infusion of immunoglobulin in the treatment of systemic lupus erythematosus. Methods 100 patients with systemic lupus erythematosus admitted to our hospital from December 2015 to December 2018 were selected and randomly divided into two groups,with 50 cases in each group.The control group was given intravenous infusion of cyclophosphami, oral prednisone,methylprednisolone shock treatment. The observation group was treated with large dose intravenous infusion of immunoglobulin based on the treatment of the control group. The therapeutic effects between the two groups were observed and compared. Results The average time of platelet peak in the observation group was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05). There were no significant differences in the systemic lupus erythematosus disease activity index(SLEDAI) and the systemic lupus erythematosus quality of life scale(SLE-QOL) score between the two groups before treatment(P>0.05). After treatment,the SLE-QOL score and SLEDAI score of the observation group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05). In the observation group, the percentage of platelets rising by more than 50% in the four weeks was 100%, which was significantly higher than that in the control group(76%), and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Large-dose intravenous infusion of immunoglobulin has a positive effect on the treatment of systemic lupus erythematosus, which can control disease activity, improve patients’ quality of life,and will not increase adverse reactions.
作者
陈希
周春燕
CHEN Xi;ZHOU Chunyan(Department of Blood Rheumatology,Chongqing Kaizhou District People's Hospital,Chongqing405400,China;Department of Gastroenterology,Chongqing Kaizhou District People's Hospital,Chongqing405400,China)
出处
《中国现代医生》
2020年第3期130-132,共3页
China Modern Doctor
关键词
大剂量
静脉滴注
免疫球蛋白
系统性红斑狼疮
Large dose
Intravenous drip
Immunoglobulin
Systemic lupus erythematosus
作者简介
通讯作者:周春燕。
