摘要
目的探讨环磷酰胺联合人免疫球蛋白治疗系统性红斑狼疮的疗效。方法以我院80例系统性红斑狼疮患者作为观察对象,将其随机将其分成两组,每组各40例。对照组给予环磷酰胺联合强的松治疗,观察组在此基础上联合人免疫球蛋白治疗,比较两组的治疗效果。结果治疗后,两组患者血清单核细胞趋化蛋白-4和白细胞介素-4均低于治疗前,组间对比,差异具有统计学意义(P<0.05);观察组治疗总有效率为92.5%,对照组治疗总有效率为70.0%,组间比较,差异有统计学意义(P<0.05)。两组治疗后均有不同程度不良反应,组间比较,差异无统计学意义(P>0.05)。结论环磷酰胺联合人免疫球蛋白治疗系统性红斑狼疮的疗效显著。
Objective To investigate the efficacy of cyclophosphamide combined with Human Immunoglobulin in the treatment of systemic lupus erythematosus. Methods 80 cases of systemic lupus erythematosus patients were randomly divided into two groups in our hospital, 40 cases in each group. Control group was treated with cyclophosphamide and prednisone. The observation group also was treated with immunoglobulin treatment. Treatment effect was then compared. Results The protein serum monocyte-4 and IL-4 of two groups after treatment were lower than before treatment, the differences between groups were statistically significant（P〈0.05）. The total efficiency of the observation group was 92.5%, the control group was 70.0%. The difference was statistically significant（P〈0.05）. Two groups had different degrees of adverse reactions after treatment, there was no significant difference in the incidence of adverse reactions（P〉0.05）. Conclusion Cyclophosphamide combined with human immunoglobulin is effective in the treatment of systemic lupus erythematosus.
作者
胡晓萍
HU Xiaoping(Blood Department of Rheumatism, Peking University Medical Luzhong Hospital, Zibo Shandong 255400, Chin)
出处
《中国继续医学教育》
2017年第3期161-163,共3页
China Continuing Medical Education
关键词
环磷酰胺
人免疫球蛋白
系统性红斑狼疮
疗效
cyclophosphamide
human immunoglobulin
systemic lupus erythematosus
efficacy
