摘要
目的系统评价维生素A补充对变应性疾病的临床作用。方法检索万方、维普、中国知网、Medline、PubMed、EBSCO等数据库,查找维生素A补充与哮喘、喘息、过敏、湿疹、肺功能等变应性疾病相关的临床随机对照试验,检索时限为建库至2018年9月30日。2位评价者按标准独立进行文献筛选、质量评价和数据提取,采用Revman 5.3软件进行Meta分析。结果维生素A补充可增加女童过敏反应发病率(P<0.05)及成人迟发型过敏反应阳性率(P<0.05),维生素A补充与儿童喘息、湿疹发病无明显相关性(P>0.05)。结论维生素A补充可能增加过敏风险,但对儿童喘息、湿疹的影响尚待明确。
Objective To assess the evidence of therapeutic effects of vitamin A on allergic disease.Methods Databases were searched for collecting the randomized controlled trials(RCTs)of the effects of vitamin A supplementation on allergic disease in human models from inception to September 30 th,2018.Studies were critically appraised,and meta-analyses were then performed using RevMan5.3 software.Result Supplementation of vitamin A increased the risk of girls′atopy(P<0.05)and the responses of delayed-hypersensitivity(P<0.05),while significant differences were not found in wheeze or eczema between the experimental group and control group(P>0.05).Conclusion Vitamin A supplementation may increase the risk of allergy,its effect on wheeze and eczema is controversial.
作者
陈沁竹
徐王国
CHEN Qin-zhu;XU Wang-guo(Yongchuan Hospital of Chongqing Medical University,Yongchuati,Chongqing 402160,China)
出处
《中国儿童保健杂志》
CAS
2020年第2期172-177,共6页
Chinese Journal of Child Health Care
作者简介
陈沁竹(1990-),女,重庆人,主治医师,硕士学位,主要研究方向为儿童呼吸系统疾病相关研究;通讯作者:徐王国,E-mail:443991158@qq.com。
