摘要
目的探讨吡拉西坦、奥拉西坦的药理及在脑卒中认知功能障碍中的临床应用效果。方法选取2016年8月至2018年8月本院收治的120例脑卒中认知功能障碍患者,按照抽签方式分为对照组和观察组,各60例,对照组患者采取吡拉西坦治疗,观察组采取奥拉西坦治疗,比较两组患者临床疗效、治疗前后MoCA、MMSE、ADL各项评分及不良反应情况。结果观察组和对照组临床有效率分别为93.33%、70.00%,观察组高于对照组,差异具有统计学意义(P<0.05);观察组不良反应发生率(3.33%)明显低于对照组(11.67%),差异具有统计学意义(P<0.05);治疗前,两组患者MoCA、MMSE、ADL各项评分比较差异无统计学意义,治疗后,观察组优于对照组,差异具有统计学意义(P<0.05)。结论奥拉西坦能有效改善患者认知功能障碍,其临床疗效比吡拉西坦更优,且不良反应少,安全性高。
Objective To investigate the pharmacology of piracetam and oracetam and its clinical effect in cerebral apoplexy with cognitive dysfunction.Methods From August 2016 to August 2018 treated 120 cases of cerebral apoplexy patients with cognitive dysfunction were selected in our hospital,according to the lottery they were divided into control group and observation group,with 60 cases ineach group,control group was treated piracetam treatment,observation group was treated oxetam treatment,clinical efficacy of two groups of patients,MoCA,MMSE,ADL scores before and after the treatment,and adverse reactions were compared between two groups.Results The clinical effective rate of observation group and control group was 93.33%and 70.00%,respectively.The difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(3.33%)was significantly lower than that in the control group(11.67%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in MoCA,MMSE and ADL scores between the two groups.After treatment,the observation group was better than the control group,with statistically significant difference(P<0.05).Conclusion Oxiracetam can effectively improve the cognitive dysfunction of patients,its clinical effect is better than piracetam,and less adverse reactions,high safety.
作者
徐骏鹏
翁合妹
Xu Junpeng;Weng Hemei(Department of Pharmacy,People's Hospital,Zengcheng District,Guangzhou,Guangdong,511300,China)
出处
《当代医学》
2020年第9期38-40,共3页
Contemporary Medicine
关键词
吡拉西坦
奥拉西坦
药理分析
临床疗效
Piracetam
Oxetam
Pharmacological analysis
Clinical curative effect
