摘要
目的分析血清可溶性髓系细胞触发受体1(sTREM-1)水平、C反应蛋白/白蛋白(CRP/Alb)比值在肺癌患者术后肺部感染早期的诊断价值。方法选取2017年6月~2018年9月在本院进行肺癌手术治疗的患者105例作为研究对象,根据患者是否发生肺部感染分为非感染组93例和感染组12例,同时选取同时间段在本院体检健康者55例作为对照组。利用酶联免疫吸附法(ELISA)检测血清sTREM-1、CRP、Alb水平,并计算CRP/Alb比值;通过绘制受试者工作特征曲线(ROC),评价sTREM-1、CRP/Alb比值对肺癌术后肺部感染早期诊断价值;对影响肺癌患者术后肺部感染的危险因素进行分析。结果与对照组、非感染组相比,感染组血清sTREM-1、CRP、CRP/Alb水平均显著升高(P<0.05),Alb水平显著降低(P<0.05)。ROC曲线显示,sTREM-1、CRP/Alb水平预测肺癌患者术后肺部感染的曲线下面积(AUC)分别为0.788(敏感度81.8%、特异性75.8%)和0.879(敏感度90.9%、特异性78.9%)。经Logistic多因素回归分析显示,贫血、糖尿病、心脑血管病以及吸烟是肺癌术后肺部感染的独立危险因素(P<0.05)。结论sTREM-1、CRP/Alb水平在肺癌术后肺部感染患者中呈现高水平,对肺癌术后肺部感染早期诊断中具有较高的辅助诊断价值。
Objective To analyze the value of serum soluble trigger receptor-1(sTREM-1)level and C-reactive protein/albumin(CRP/Alb)ratio in early diagnosis of pulmonary infection in patients with lung cancer after operation.Methods From June 2017 to September 2018,105 patients with lung cancer underwent surgical treatment in our hospital were selected as the research objects.According to whether the patients had pulmonary infection or not,they were divided into non-infected lung cancer group(93 cases)and non-infected lung cancer group(12 cases).At the same time,55 healthy people were selected as the control group during the same period.Levels of serum sTREM-1,CRP and Alb were detected by enzyme-linked immunosorbent assay(ELISA),and the CRP/Alb ratio was calculated.The values of sTREM-1 and CRP/Alb ratio in early diagnosis of post-operative infection of lung cancer were evaluated by drawing ROC.The risk factors of pulmonary infection in patients with lung cancer after operation were analyzed.Results Compared with the control group and the non-infected lung cancer group,the levels of serum sTREMl,CRP and CRP/Alb in the infected group increased significantly(P<0.05),while the level of Alb decreased significantly(P<0.05).ROC curve showed that the areas under curve(AUC)of sTREM1 and CRP/Alb levels predicting pulmonary infection after lung cancer surgery were 0.788(sensitivity and specificity were 81.8%and 75.8%)and 0.879(sensitivity and specificity were 90.9%and 78.9%),respectively.Logistic regression analysis showed that anemia,diabetes mellitus,cardiovascular and cerebrovascular diseases and smoking were independent risk factors for pulmonary infection after lung cancer surgery(P<0.05).Conclusion The levels of sTREM-1 and CRP/Alb are high in patients with post-operative infection of lung cancer,and both of them have high values in early diagnosis of post-operative infection of lung cancer,which are risk factors for pulmonary infection after lung cancer surgery.
作者
邱浩
赵志宏
程丰
宋耀林
QIU Hao;ZHAO Zhihong;CHENG Feng;SONG Yaolin(Department of Cardiothoracic Surgery,Ezhou Central Hospital,Ezhou 436000,Hubei,China)
出处
《西部医学》
2020年第3期443-447,共5页
Medical Journal of West China
