摘要
目的:分析质子泵抑制剂联合抗生素治疗对Hp阳性慢性萎缩性胃炎(CAG)患者血清胃泌素(GAS)、可溶性白介素-2受体(sIL-2R)、C-反应蛋白(CRP)水平及免疫功能的影响。方法:选取2016年4月至2018年4月儋州市人民医院收治的Hp阳性CAG患者150例为研究对象,随机分为观察组、对照组,均75例,对照组予以质子泵抑制剂,观察组另加服抗生素(克拉霉素、阿莫西林),均治疗6周后对比两组治疗总有效率、Hp根除率、治疗前后血清GAS、sIL-2R、CRP水平及免疫功能(T细胞亚群CD4+、CD8+、CD4+/CD8+)、不良反应。结果:观察组治疗总有效率77.33%明显高于对照组61.33%(P<0.05);观察组Hp根除率74.67%高于对照组42.67%(P<0.05);治疗后观察组血清GAS水平高于对照组,而sIL-2R、CRP水平低于对照组(P<0.05);观察组治疗后血CD4+、CD4+/CD8+含量高于对照组,而CD8+含量低于对照组(P<0.05);观察组治疗前后GAS、sIL-2R、CRP变化差值及血CD4+、CD8+、CD4+/CD8+含量变化差值均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率17.33%、13.33%比较差异无统计学意义(P>0.05)。结论:质子泵抑制剂联合抗生素对Hp阳性CAG患者有较好疗效,可下调其GAS、sIL-2R、CRP水平,改善免疫功能,提高Hp根除率,且安全性好,值得在临床推广实践。
Objective:To analyze the effect of proton pump inhibitor combined with antibiotic therapy on serum gastrin(GAS),soluble interleukin-2 receptor(sIL-2R)and C-reactive protein(CRP)levels and immune functionin patients with Hppositive chronic atrophic gastritis(CAG).Methods:A total of 150 patients with Hppositive CAG admitted to the Danzhou People's Hospital from April 2016 to April 2018 were enrolled in the study.They were randomly divided into observation group and control group,75 cases in each group.The control group were treated with proton pump inhibitor,while the observation group additionally took antibiotics(clarithromycin,amoxicillin).The total effective rate of treatment,Hp eradication rate,serum GAS,sIL-2R and CRP levels,immune function(T cell subsets CD4+,CD8+,CD4+/CD8+)before and after treatment and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was significantly higher than that in the control group(77.33%vs 61.33%)(P<0.05).The Hp eradication rate in the observation group was also higher than that in the control group(74.67%vs42.67%)(P<0.05).The serum GAS level in the observation group was higher than that in the control group while levels of sIL-2R and CRP were lowerthan the control group after treatment(P<0.05).The levels of CD4+and CD4+/CD8+in the observation group were higher than those in the control group,while the content of CD8+was lower than that in the control group(P<0.05).The difference values of GAS,sIL-2R,CRP,levels of blood CD4+,CD8+and CD4+/CD8+in the observation group before and after treatment were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(17.33%vs 13.33%)(P>0.05).Conclusion:Proton pump inhibitor combined with antibiotics is effective in the treatment ofHp-positive CAG.It can downregulate levels of GAS,sIL-2R and CRP,and improve the immune function andHp eradication rate,with safety.
作者
陈朝聪
蔡水苗
刘海珊
CHEN Chaocong;CAI Shuimiao;LIU Haishan(Danzhou People's Hospital, Hainan Danzhou 571700, China)
出处
《河北医学》
CAS
2020年第3期429-432,共4页
Hebei Medicine
基金
海南省自然科学基金，(编号:2016021378)
