摘要
目的探讨红藤联合脉通散外敷对肺癌伴下肢深静脉血栓患者血液流变学及血栓弹力图的影响。方法选取2016年7月~2018年7月重庆大学附属肿瘤医院接诊的肺癌伴下肢深静脉血栓形成患者52例,依据随机数字表法分为治疗组和对照组,每组各26例。对照组给予低分子肝素钙治疗;治疗组在对照组的基础上给予红藤联合脉通散外敷治疗,共治疗2个疗程。比较两组临床效果、患肢周径差、全血高切黏度(HBV)、全血低切黏度(LBV)、纤维蛋白原(FIB)、血栓弹力图K值。结果治疗组总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗组髌骨上缘、下缘15 cm周径差低于对照组,差异有统计学意义(P<0.05)。治疗前,两组HBV、LBV和FIB水平比较,差异无统计学意义(P>0.05);治疗后HBV、LBV和FIB水平均低于治疗前,且治疗组低于对照组,差异均有统计学意义(均P<0.05)。治疗前,两组血栓弹力图K值比较,差异无统计学意义(P>0.05);治疗后血栓弹力图K值高于治疗前,且治疗组高于对照组,差异均有统计学意义(均P<0.05)。结论红藤联合脉通散外敷对肺癌伴下肢深静脉血栓患者效果确切,显著改善血液流变学指标及血栓弹力图K值,值得应用于临床。
Objective To investigate the effect of Sargentodoxae Caulis combined with Maitong Powder exteral application on hemorheology and thromboelastic elasticity of lung cancer patients with lower extremity deep venous thrombosis.Methods From July 2016 to July 2018,a total of 52 cases with lung cancer patients with lower extremity deep venous thrombosis were admitted to Chongqing University Cancer Hospital.According to the random number table method,they were divided into the treatment group and the control group,with 26 cases in each group.The control group was treated with Low Molecular Weight Heparin Calcium.The treatment group was treated with Sargentodoxae Caulis combined with Maitong Powder on the basis of the control group for 2 courses of treatment.Clinical efficacy,circumference diameter of affected limb difference,high blood viscosity(HBV),low blood viscosity(LBV),fibrinogen(FIB)and K value of thrombolytic elasticity were compared between the two groups.Results The total effective rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The difference of 15 cm circumference between the upper and lower edges of the patella in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference with HBV,LBV and FIB levels in the two groups(P>0.05).After treatment,the levels of HBV,LBV and FIB in the two groups were all lower than those before treatment,and the treatment group were lower than the control group,with statistically significant differences(P<0.05).Before treatment,there was no significant difference in the K value of thrombolytic elasticity between the two groups(0.05).After treatment,the K value of thrombolytic elasticity was higher than that before treatment,and the treatment group was higher than the control group,with statistically significant differences(all P<0.05).Conclusion Sargentodoxae Caulis combined with Maitong Powder external application have a definite effect on patients with lung cancer with deep vein thrombosis of lower extremities,which can significantly improve hemorheology indexes and K value of thrombolytic elasticity,and it is worthy of clinical application.
作者
陈红
王维
李配富
肖彩芝
CHEN Hong;WANG Wei;LI Peifu;XIAO Caizhi(Department of Traditional Chinese Medicine Oncology,Chongqing University Cancer Hospital,Chongqing400030,China)
出处
《中国医药导报》
CAS
2020年第5期156-159,共4页
China Medical Herald
基金
重庆市卫生计生委中医药科技项目（ZY201702040）
关键词
红藤
脉通散
肺癌
下肢深静脉血栓形成
血栓弹力图
Sargentodoxae Caulis
Maitong Powder
Lung cancer
Lower extremity deep vein thrombosis
Thrombolytic elasticity
作者简介
陈红(1981-),女,硕士,副主任医师;研究方向:中西医结合肿瘤学;通讯作者:王维(1980-),女,博士,副主任医师;研究方向:中西医结合肿瘤学。
