摘要
目的探讨血清糖类抗原199(CA199)、糖类抗原50(CA50)、癌胚抗原(CEA)联合粪便检验对直肠癌的诊断价值。方法将自贡市第三人民医院自2016年1月至2018年9月收治的60例直肠癌患者纳入B组,将同期60例体检者纳入A组。两组研究对象均接受血清CA199、CA50、CEA及粪便检验。比较两组研究对象血清CA199、CA50、CEA水平及阳性率,粪便检验结果,各项检查敏感性、特异性、Youden指数。结果 B组血清CA199、CA50、CEA水平及阳性率均高于A组,差异有统计学意义(P<0.05)。B组细条样粪便、血便、黏液便、脓血便、隐血试验阳性比例均高于A组,差异有统计学意义(P<0.05)。CA199+粪便检验、CA199+CA50+粪便检验、CA199+CA50+CEA+粪便检验的敏感性、特异性、Youden指数均呈逐渐上升趋势。结论血清CA199、CA50、CEA联合粪便检验对直肠癌的临床诊断参考价值较高,可有效提高直肠癌的检出效率。
Objective To investigate the diagnostic value of serum carbohydrate antigen 199(CA199),carbohydrate antigen 50(CA50) and carcinoembryonic antigen(CEA) combined with fecal test for rectal cancer.Methods A retrospective study was performed on 60 cases of patients with rectal cancer who were admitted from January 2016 to September 2018(Group B),the other 60 cases of patients who underwent physical examination in the same period were included in Group A.Both groups were tested for serum CA199,CA50,CEA and feces.Serum CA199,CA50,CEA levels and positive rates,fecal test results,sensitivity,specificity and Youden index were compared between the two groups.Results The serum levels and positive rates of CA199,CA50 and CEA in Group B were higher than those in Group A,with statistically significant differences(P<0.05).In Group B,the positive ratio of fine strip stool,blood stool,mucus stool,pus blood stool and occult blood test was higher than that of Group A(P<0.05).The sensitivity,specificity and Youden index of CA199+fecal test,CA199+CA50+fecal test and CA199+CA50+CEA+fecal test were all on the rise.Conclusion Serum CA199,CA50 and CEA combined with fecal test have a high reference value in the clinical diagnosis of rectal cancer,which can effectively improve the detection efficiency of rectal cancer.
作者
刘益
周自忠
刘刚
徐海荣
LIU Yi;ZHOU Zi-zhong;LIU Gang;XU Hai-rong(Department of Gastroenterology,Third People's Hospital of Zigong City,Zigong 643000,China)
出处
《临床军医杂志》
CAS
2019年第12期1335-1336,共2页
Clinical Journal of Medical Officers
关键词
直肠癌
糖类抗原199
糖类抗原50
癌胚抗原
粪便检验
Colorectal cancer
Carbohydrate antigen 199
Carbohydrate antigen 50
Carcinoembryonic antigen
Fecal test
作者简介
第一作者:刘益(1985-),男,四川泸州人,主治医师。
