摘要
目的探讨腹腔镜手术治疗卵巢良性肿瘤的临床效果及对患者生殖激素、体液及细胞免疫功能的影响。方法选取2017年2月至2018年2月收治的良性卵巢肿瘤患者118例,采用随机数字表法分为微创组和传统组,每组59例。微创组采用腹腔镜手术治疗,传统组采用传统开腹手术治疗。对比2组患者的围手术期相关指标、手术前后的血清雌激素(E2)、黄体生成素(LH)、促卵泡激素(FSH)、血清免疫球蛋白及外周血T淋巴细胞亚群。结果微创组患者的手术时间、术中出血量、术后肛门排气时间、住院时间均显著低于传统组(P<0.05)。术前2组患者的血清E2、LH、FSH水平差异无统计学意义(P>0.05);术后微创组患者的血清E2高于传统组(P<0.05),LH、FSH水平低于传统组(P<0.05)。术前2组患者的CD3+、CD4+、CD8+、CD4+/CD8+水平差异无统计学意义(P>0.05);术后微创组患者的CD3+、CD4+、CD4+/CD8+水平高于传统组(P<0.05),CD8+水平低于传统组(P<0.05)。术前2组患者的IgG、IgM、IgA水平差异无统计学意义(P>0.05);术后微创组患者的IgG水平高于传统组(P<0.05),IgM、IgA水平与传统组差异无统计学意义(P>0.05)。结论腹腔镜手术治疗卵巢良性肿瘤具有创伤小、恢复快、对患者的生殖激素水平、免疫功能影响更小的特征。
Objective To investigate the clinical curative effects of laparoscopic surgery in treatment of benign ovarian tumors and its effects on reproductive hormones,humoral and cellular immunity of patients.Methods A total of 118 patients with benign ovarian tumors who were admitted and treated in our hospital from February 2017 to February 2018 were emrolled in the study,who were divided into the minimally invasive group(n=59)and the traditional treatment group(n=59)according to random digital table method.The patients in minimally invasive group were treated by laparoscopy,however,the patients in traditional treatment group were treated by traditional laparotomy.The perioperative phase indexes including serum estrogen(E2),LH,the follicle stimulating hormone,serum immunoglobulin and peripheral blood T lymphocyte subsets before and after the operation were observed and compared between the two groups.Results The operation time,intraoperative blood loss,the time of anal exhaust after operation and hospitalization time in minimally invasive group were significantly lower than those in traditional treatment group(P<0.05).Befeore operation there were no statistically significant differences in the serum levels of E2,LH and FSH between the two groups(P>0.05).After operation the serum levels of E2 in minimally invasive group were significantly higher than those in traditional treatment group(P<0.05),however,the levels of LH and FSH were significantly lower than those in traditional treatment group(P<0.05).Befeore operation there were no statistically significant differences in the levels of CD3+,CD4+,CD8+and CD4+/CD8+between the two groups(P>0.05).After the operation,the levels of CD3+,CD4+,CD8+and CD4+/CD8+in minimally invasive group were significantly higher than those in traditional treatment group(P<0.05),however,the levels of CD8+were significantly lower than those in traditional treatment group(P<0.05).Before the operation,there were no significant differences in the levels of IgG,IgM,IgA between the two groups(P>0.05).After operation the levels of IgG in minimally invasive group were significantly higher than those in traditional treatment group(P<0.05),however,there were no significant differences in the levels of IgM,IgA between the two groups(P>0.05).Conclusion Laparoscopic surgery in treatment of benign ovarian tumors has the advantages of less trauma,faster recovery,less effects on reproductive hormone level and immune function of patients.
作者
马国芳
MA Guofang(Qinghai Provincial Women and Children's Hospital, Qinghai,Xining 810007,China)
出处
《河北医药》
CAS
2020年第1期85-87,91,共4页
Hebei Medical Journal
关键词
腹腔镜
卵巢良性肿瘤
生殖激素
免疫功能
laparoscopy
ovarian benign tumor
reproductive hormone
immune function
