摘要
本研究运用多种色谱技术从夹竹桃叶内生真菌Colletotrichum sp.HK-08中分离得到11个化合物,利用波谱学方法鉴定其结构分别为butyl 2-(4-hydroxyphenyl)acetate(1)、4-hydroxyphenethyl acetate(2)、phenethyl 2-phenylacetate(3)、phenethyl 2-(4-hydroxyphenyl)acetate(4)、4-hydroxyphenethyl 2-(2-hydroxyphenyl)acetate(5)、4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate(6)、对羟基苯甲醛(7)、2-羟基苯乙醇(8)、对羟基苯甲酸(9)、对羟基苯乙酮(10)和3a-hydroxyindoline(11)。其中化合物4、5和11为新的天然产物,化合物1~6和11为首次从Colletotrichum属真菌中分离得到。活性测试结果显示,化合物4和6表现出一定的细胞毒活性。
Eleven compounds were isolated and purified from the endophytic fungus Colletotrichum sp.HK-08 from the leaves of Nerium indicum by various chromatographic techniques,and the structures were identified as butyl 2-(4-hydroxyphenyl)acetate(1),4-hydroxyphenethyl acetate(2),phenethyl 2-phenylacetate(3),phenethyl 2-(4-hydroxyphenyl)acetate(4),4-hydroxyphenethyl 2-(2-hydroxyphenyl)acetate(5),4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate(6),4-hydroxybenzaldehyde(7),2-(2-hydroxyethyl)phenol(8),4-hydroxybenzoic acid(9),1-(4-hydroxyphenyl)ethenone(10)and 3a-hydroxyindoline(11).Among them,compounds 4,5 and 11 were new natural products,and 1~6 and 11 were isolated from Colletotrichum sp.for the first time.The bioactivity results showed that compounds 4 and 6 exhibited certain cytotoxic activities.
作者
郑浩
梅文莉
蔡彩虹
盖翠娟
戴好富
谭志琼
陈惠琴
ZHENG Hao;MEI Wen-li;CAI Cai-hong;GAI Cui-juan;DAI Hao-fu;TAN Zhi-qiong;CHEN Hui-qin(School of Life and Pharmaceutical Sciences,Hainan University,Haikou 570228,China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2020年第1期75-80,共6页
Natural Product Research and Development
基金
海南省重点研发计划(ZDYF2019217)
中国热带农业科学院院级创新团队南药产业技术创新团队(17CXTD-15)
现代农业产业技术体系建设专项(CARS-21)
作者简介
通信作者:谭志琼,E-mail:tanzhiqiong2002@163.com;通信作者:陈惠琴,E-mail:chenhuiqin@itbb.org.cn。
