摘要
目的探讨石斛养胃汤联合西药治疗慢性萎缩性胃炎(CAG)的临床效果。方法选取2018年1月~2019年1月南昌市洪都中医院收治的CAG患者100例,按随机数字表法分为对照组(50例,替普瑞酮+胶体果胶铋治疗)和研究组(50例,石斛养胃汤+替普瑞酮+胶体果胶铋治疗)。比较两组临床疗效、中医症状积分、炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、氧化应激指标[一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)]及血清胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平及不良反应。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后胃刺痛、食少纳呆、消瘦、倦怠乏力及胃脘胀满积分均低于治疗前,且研究组低于对照组(P<0.05)。两组治疗后CRP、TNF-α及IL-6水平均低于治疗前,且研究组低于对照组(P<0.05);两组治疗后G-17、PGⅠ、PGⅡ水平均高于治疗前,且研究组高于对照组(P<0.05)。两组治疗后NO、SOD水平均高于治疗前,且研究组高于对照组(P<0.05);两组治疗后MDA水平低于治疗前,且研究组低于对照组(P<0.05)。两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论石斛养胃汤联合西药治疗CAG效果确切,可明显改善患者临床症状,安全性较高,可为临床治疗CAG提供参考。
Objective To explore clinical effect of Shihu Yangwei Decoction combined with Western medicine in the treatment of chronic atrophic gastritis(CAG).Methods One hundred patients with CAG who were admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from January 2018 to January 2019 were selected.The patients were randomly divided into control group(50 cases,Teprenone+Colloidal Bismuth Pectin therapy)and study group(50 cases,Shihu Yangwei Decoction+Teprenone+Colloidal Bismuth Pectin therapy)according to stratified randomization method.The clinical efficacy,traditional Chinese medicine symptom score,the levels of inflammatory factor[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],oxidative stress index[nitric oxide(NO),superoxide dismutase(SOD),malondialdehyde(MDA)and serum gastrin-17(G-17),pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)indicators and adverse reactions between two groups were compared.Results The total effective rate in study group was higher than that in control group(P<0.05).After treatment,the scores of stomach tingling,food shortage,wasting,fatigue and fullness of stomach in two groups were lower than those before treatment,and the scores in study group were lower than those in control group(P<0.01).After treatment,CRP,TNF-αand IL-6 in two groups were lower than those before treatment,and that in study group was lower than that in control group(P<0.01).After treatment,the levels of G-17,PGⅠand PGⅡin two groups were higher than those before treatment,and the level in study group was higher than that in control group(P<0.01).The levels of NO and SOD in two groups were higher than those before treatment,and the level in study group was higher than that in control group(P<0.01).MDA level of two groups after treatment was lower than that befo treatment,and that of study group was lower than that of control group(P<0.01).There was no significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Shihu Yangwei Decoction combined with Western medicine has definite curative effect on CAG.It can significantly improve the clinical symptoms,it has high safety.It can provide reference for clinical treatment of CAG.
作者
王文莉
万青
戴卉
WANG Wenli;WAN Qing;DAI Hui(Department of Pharmacy,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Jiangxi Province,Nanchang330000,China;Department of Internal Chinese Medicine,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Jiangxi Province,Nanchang330000,China)
出处
《中国医药导报》
CAS
2020年第2期139-143,共5页
China Medical Herald
基金
江西省卫生计生委科技计划项目(20167229)
关键词
石斛养胃汤
慢性萎缩性胃炎
西药
Shihu Yangwei Decoction
Chronic atrophic gastritis
Western medicine
作者简介
王文莉(1974.7-),女,副主任中药师,研究方向:临床中药学、中药制药。
