摘要
目的:探讨胰岛素强化治疗对初诊2型糖尿病(T2DM)患者血清炎症因子、氧化应激的影响。方法:初诊T2DM患者75例随机分为对照组35例和观察组40例。对照组患者口服二甲双胍治疗,观察组患者给予胰岛素泵强化治疗。治疗2周后,比较两组患者血糖、糖化血红蛋白(HbA1c)水平变化及血糖达标时间,以及治疗前后炎症因子、氧化应激水平变化。结果:两组患者治疗后空腹血糖(FPG)、餐后2 h血糖(2hPG)、HbA1c水平较治疗前明显下降(P<0.05),且观察组患者FPG、2hPG、HbA1c水平明显低于对照组(P<0.05),血糖达标时间明显少于对照组(P<0.05)。两组患者治疗后C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平和血浆丙二醛(MDA)水平较治疗前明显下降(P<0.05),超氧化物歧化酶(SOD)、还原型谷胱甘肽(RGSH)水平较治疗前明显升高(P<0.05);且观察组患者除RGSH外其他各项指标均显著优于对照组(P<0.05)。结论:胰岛素泵强化治疗能显著提高初诊T2DM患者的治疗效果,缩短血糖达标时间,减轻炎症反应及氧化应激,值得临床推广应用。
Objective:To investigate the effects of intensive insulin therapy on serum inflammatory factors and oxidative stress in newly diagnosed type 2 diabetes mellitus(T2 DM)patients.Methods:A total of 75 cases of newly diagnosed T2 DM patients were divided into control group(35 cases)and observation group(40 cases)according to the random number table method,the patients in the control group were treated with metformin orally,the patients in the observation group were given insulin pump intensive treatment.After 2 weeks of treatment,the levels of blood glucose,glycosylated hemoglobin(HbA1 c)and the time of blood glucose reaching target,as well as the change of inflammatory factors and oxidative stress levels before and after treatment in the two groups were compered.Results:The levels of fasting blood sugar(FPG),2 h postprandial blood glucose(2 hPG)and HbA1 c in the two groups were significantly lower than those before treatment(P<0.05),and the levels of FPG,2 hPG and HbA1 c in the observation group were significantly lower than those in the control group(P<0.05);The time of blood glucose reaching target was significantly shorter than that of the control group(P<0.05);After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)and plasma malondialdehyde(MDA)in the two groups were significantly decreased(P<0.05),and the levels of superoxide dismutase(SOD)and reduced glutathione(RGSH)in the two groups were significantly increased(P<0.05);In addition,the observation group was significantly better than the control group in all other indicators except RGSH(P<0.05).Conclusion:Insulin pump intensive treatment can significantly improve the treatment of newly diagnosed T2 DM patients,shorten the time of blood glucose reaching target,reduce inflammation and oxidative stress,which is worth popularizing in clinical application.
作者
楼时先
刘心雨
郑伟英
Lxju Shixian;Liu Xinyu;Zheng Weiying(Department of Endocrinology,Jinhua People’s Hospital,Jinhua 321000,Zhejiang,China)
出处
《药物流行病学杂志》
CAS
2019年第12期792-795,共4页
Chinese Journal of Pharmacoepidemiology
关键词
2型糖尿病
胰岛素强化治疗
炎症因子
氧化应激
Type 2 diabetes
Intensive insulin therapy
Inflammatory cytokines
Oxidative stress
作者简介
通讯作者:楼时先,Tel:13819993918 E-mail:1041668250@qq.com。
