摘要
目的:观察在西医常规治疗基础上联合中药复方蝉芩颗粒治疗咳嗽变异性哮喘(CVA)的临床疗效。方法:纳入CVA患者80例,随机分为治疗组与对照组,每组各40例。两组患者均给予福莫特罗/布地奈德吸入治疗,治疗组联合蝉芩颗粒口服,对照组联合安慰剂口服,治疗周期为4周。治疗2周、4周后,评价两组患者的中医证候疗效;比较两组的中医证候积分和咳嗽视觉模拟评分;采用莱彻斯特咳嗽问卷(LCQ)评价患者的生活质量;检测并比较两组患者的呼出气一氧化氮(FeNO)。治疗后随访1年,比较两组患者的远期疗效。结果:治疗2周后,对照组的中医证候疗效总有效率为52.5%,治疗组为80.0%,治疗组的疗效优于对照组(P<0.01);两组患者的中医证候积分、咳嗽视觉模拟评分较治疗前均显著降低(P<0.05,P<0.01),且治疗组患者的评分低于对照组(P<0.05);治疗组患者的LCQ各维度评分及总分较治疗前均升高(P<0.01),对照组患者的LCQ心理健康维度评分及总分较治疗前亦升高(P<0.05),且治疗组患者的各维度评分及总分均高于对照组(P<0.05)。治疗4周后,对照组的中医证候疗效总有效率为80.0%,治疗组为90.0%,治疗组的疗效优于对照组(P<0.05);两组患者的中医证候积分、咳嗽视觉模拟评分及FeNO水平较治疗前均显著下降(P<0.01),但两组间比较差异无统计学意义(P>0.05);两组患者的LCQ各维度评分及总分较治疗前均显著升高(P<0.01),但两组间比较差异无统计学意义(P>0.05)。治疗后随访1年,治疗组患者的远期疗效优于对照组(P<0.05)。结论:西医常规治疗联合蝉芩颗粒口服可在治疗早期快速改善CVA患者的气道症状,具有较好的临床疗效。
Objective:To observe the clinical efficacy of Chanqin Granule based on routine western medicine in the treatment of cough variant asthma(CVA). Methods:Eighty patients with CVA were included and randomly divided into the treatment group and the control group, 40 cases in each group. The patients in both groups were treated with formoterol/budesonide inhalation. In addition, the patients in the treatment group were orally treated with Chanqin Granule and the patients in the control group were orally treated with placebo. The treatment course was 4 weeks. After treatment for 2 and 4 weeks, the efficacy of Chinese medical syndrome in both groups were evaluated, and the Chinese medical syndrome scores and the visual analogue score of cough were compared between the two groups;the quality of life was evaluated by Leicester cough questionnaire(LCQ);the fractional exhaled nitric oxide(FeNO) was detected and compared between the two groups. After treatment, the patients were followed-up for one year, and the long-term efficacy was compared between the two groups. Results:After treatment for 2 weeks, the total effective rates on Chinese medical syndrome of the control group and the treatment group were 52.5% and 80.0% respectively, and the efficacy of the treatment group was better than that of the control group(P<0.01);the Chinese medical syndrome scores and the visual analogue scores of cough in both groups were significantly decreased compared with treatment before( P<0.05,P<0.01),and the scores of the treatment group were lower than those of the control group( P<0.05);the scores of all dimensions in LCQ and the total score in the treatment group were increased compared with treatment before( P<0.01),the score of psychological health dimension in LCQ and the total score in the control group were also increased compared with treatment before( P<0.05),and the scores of all dimensions and the total score in the treatment group were higher than those in the control group( P<0.05). After treatment for 4 weeks,the total effective rates on Chinese medical syndrome of the control group and the treatment group were 80.0% and 90.0% respectively,and the efficacy of the treatment group was better than that of the control group( P<0.05);the Chinese medical syndrome score,the visual analogue score of cough and the level of Fe NO were significantly decreased in both groups compared with treatment before( P<0.01),but with no statistically significant differences between the two groups( P>0.05);the scores of all dimensions in LCQ and the total score were obviously increased in both groups compared with treatment before( P<0.01),but with no statistically significant differences between the two groups( P>0.05). During the follow-up for one year,the long-term efficacy of the treatment group was better than that of the control group( P<0.05). Conclusion: Routine western medical therapy combined with Chanqin Granule can rapidly improve the airway symptoms of patients with CVA in the early treatment stage,which shows good clinical efficacy.
作者
陈旋
孟令一
陈麒
CHEN Xuan;MENG Lingyi;CHEN Qi(Department of Pulmonary Disease,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Tianshan Hospital of Traditional Chinese Medicine,Changning District,Shanghai 200436,China)
出处
《上海中医药大学学报》
CAS
2019年第6期22-26,共5页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市卫计委青年基金资助项目(20164Y0199)
上海市中医临床重点实验室项目
关键词
咳嗽变异性哮喘
蝉芩颗粒
中西医结合
cough variant asthma
Chanqin Granule
integrated Chinese and western medicine
作者简介
陈旋,女,博士,主治医师,主要从事中西医结合治疗呼吸道疾病临床研究;通信作者:孟令一,主治医师;E-mail:menglingyi@163.com。
