摘要
目的:观察火针联合电针法治疗带状疱疹的临床疗效及其对血清细胞因子IL-4、TNF-α水平的影响。方法:带状疱疹患者40例,中心随机分为火针联合电针组(12例,予火针联合电针治疗)、电针组(12例,予单纯电针治疗)、西药组(21例,其中脱落5例,予单纯西药治疗),3组患者均每日治疗一次,10 d为1个疗程,1个疗程结束后分别评价其疗效、疼痛开始缓解时间、疼痛持续时间、症状体征量化记分表评分,并检测患者治疗前后血清因子IL-4及TNF-α的变化水平。结果:总有效率:火针联合电针组为100%(12/12);电针组为83.33%(10/12);西药组为68.75%(11/16)。治疗后,3组患者疼痛开始缓解时间及疼痛持续时间组间比较有明显差异(P<0.05),火针联合电针组、电针组较西药组时间短,且火针联合电针组时间更短。在改善带状疱疹患者症状、体征方面,3组患者组内比较,差异均具有显著统计学意义(P<0.01);治疗后组间比较,火针联合电针组对病症改善优于电针组、西药组(P<0.05);电针组与西药组对病症改善无明显差异(P>0.05)。测定血清IL-4及TNF-α的水平变化,在治疗前后组间及组内比较血清IL-4水平,均无统计学差异(P>0.05);在组内资料中对血清TNF-α水平进行比较,火针联合电针组、西药组有差异(P<0.05),电针组比较无差异(P>0.05);组间比较,3组治疗前后TNF-α的水平均无差异(P>0.05)。结论:用于治疗带状疱疹的火针联合电针疗法能快速缓解患者病痛,其临床疗效显著。
Objective:To observe the therapeutic effect of fire needle combined with electroacupuncture(EA)therapy on treating herpes zoster and the impact on the levels of serum IL-4 and TNF-α.Methods:By random method,the 40 subjects were divided into the treatment group 1(12 cases,treated with fire needle combined with EA therapy),the treatment group 2(12 cases,treated with EA)and the treatment group 3(a total of 21 casesincluding 5 cases excluded,treated with prescription medicine).Three groups were treated once a day,and 10 consecutive times was 1 course of treatment.They were treated for 1 course.And the curative effect,the pain relieving time,duration of pain relief as well as symptom and sign score were evaluated after treatment.Then the levels of IL-4 and TNF-αof serum were measured before the first treatment and after the tenth treatment respectively.Results:The total efficiency:that of the treatment group 1 was 100%(12/12),of the treatment group 2 was 83.33%(10/12)andof the treatment group 3 was 68.75%(11/16).After treatment,three groupshad significant difference in the pain relieving time and duration of pain(P<0.05).Those of the treatment group 1 and the treatment group 2 were shorter than those of the treatment group 3,and those of the treatment group 1 was the shortest one.On quantification of symptoms and signs scores,the three groups were statistically significant before and after treatment(P<0.01).After the comparison among groups,the treatment group 1 was better than the treatment group 2 and the treatment group 3(P<0.05).There was no significant difference between the treatment group 2 and the treatment group 3(P>0.05).The serumlevelsof IL-4 among was not significant(P>0.05).In the serum level of TNF-α,there were significant differences before and after treatment between the treatment group 1 and the treatment group 3 respectively(P<0.05).There was no difference before and after treatment in the treatment group 2(P>0.05).There was no difference among the three groups before and after treatment in the level of TNF-α(P>0.05).Conclusions:The therapy of fire needle combined with EA had quite good efficacy,which could significantly alleviate pain of herpes zoster.
作者
桂星花
马朝阳
高英
李熳
毛红蓉
李凌霄
王青青
曹梦
韩婷
程黎
GUI Xinghua;MA Chaoyang;GAYing;LI Man;MAO Hongrong;LI Lingxiao;WANG Qingqing;CAO Meng;HAN Ting;CHENG Li(Wuhan Youfu Hospital,Wuhan 430000,Hubei,China;Wuhan Center Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430014,Hubei,China;Department of Neurobiology,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,Hubei,China;The First Hospital in Wuhan Affiliated to Huazhong University of Science and Technology,Wuhan 430022,Hubei,China)
出处
《辽宁中医杂志》
CAS
2019年第11期2399-2404,共6页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81674057)
湖北省卫计委基金项目(2013Z-Y50)
作者简介
桂星花(1990-),女,湖北咸宁人,住院医师,硕士研究生,研究方向:针灸防治心脑血管病及神经系统疾病的研究;通讯作者:李熳(1973-),女,湖北武汉人,教授,博士研究生导师,博士,研究方向:电针镇痛机制,E-mail:liman73@mails.tjmu.ed。
