摘要
通过分析近20年中药治疗咳嗽的专利现状,探讨中药在治疗咳嗽过程中的用药规律。在SIPO专利检索平台和中国知网的专利数据库对中药治疗咳嗽的专利进行检索,采用Clementine 12.0软件进行关联性和高频中药网络分析,分析治疗咳嗽中药和配伍中药药对的使用规律。在治疗咳嗽的316首中药专利中,中药复方中使用频数最高的中药为甘草,其他使用频数较高的中药有桔梗、麻黄、陈皮、半夏等;使用的化痰止咳平喘类药偏多。常用的药对为甘草-桔梗、甘草-陈皮、半夏-甘草、麻黄-甘草。通过对中药频数、药类、药对、关联规则、高频中药网络的分析,结合中医理论可以揭示咳嗽中药复方的配伍规律,为临床用药提供依据。
To reveal the medication patterns of Chinese patent medicine in the treatment of cough based on the analysis of the patent status of Chinese materia medica(CMM)in the field of cough control in nearly 20 years.Patents of Chinese patent medicine in the treatment of cough were systematically searched in SIPO Platform and CNKI,association analysis and network analysis of high-frequency medicines were used to reveal the medication patterns of Chinese patent medicine in the treatment of cough with software Clementine 12.0.The results showed that Chinese medicine with highest frequency in 316 formulas was Glycyrrhizae Radix et Rhizoma,the other Chinese herbs with higher frequency were Platycodonis Radix,Ephedrae Herba,Citri Reticulatae Pericarpium,Pinelliae Rhizoma,etc.The main categories were the medicines used to treat cough and asthma,as well as to reduce phlegm.The commonly used herbal pairs were Glycyrrhizae Radix et Rhizoma-Platycodonis Radix,Glycyrrhizae Radix et Rhizoma-Citri Reticulatae Pericarpium,Pinelliae Rhizoma-Glycyrrhizae Radix et Rhizoma,Ephedrae Herba-Glycyrrhizae Radix et Rhizoma,etc.It was concluded that the medication patterns of Chinese patent medicine in the treatment of cough can be revealed based on the analysis of the herbal frequency,herbal pairs,association rules,and the network of high-frequency medicines and the theory of traditional Chinese medicine,so as to provide reference evidences for clinical medication.
作者
丁天宇
覃文慧
郝二伟
杜正彩
邓家刚
黄慧学
侯小涛
DING Tian-yu;QIN Wen-hui;HAO Er-wei;DU Zheng-cai;DENG Jia-gang;HUANG Hui-xue;HOU Xiao-tao(Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Nanning 530200,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第22期5639-5644,共6页
Chinese Traditional and Herbal Drugs
基金
广西中药药效重点实验室人才培养项目(17-259-20-P4)
广西特色药用资源金花茶产业发展关键技术与应用示范研究(桂科AA18118049)
中国东盟传统药物研究国际合作联合实验室建设(一期)(桂科AD17195025)
关键词
咳嗽
中药
专利
用药规律
甘草
桔梗
麻黄
陈皮
半夏
cough
Chinese materia medica
patent
drug utilizing regularity
Glycyrrhizae Radix et Rhizoma
Platycodonis Radix
Ephedrae Herba
Citri Reticulatae Pericarpium
Pinelliae Rhizoma
作者简介
第一作者:丁天宇(1993-),男,在读硕士,安徽合肥人,研究方向为中药制药,E-mail:1789710202@qq.com;第一作者:覃文慧,博士,从事中药、中药复方研究及实验动物模型研究,E-mail:583939070@qq.com;通信作者:黄慧学,副教授,研究方向为中药制药,E-mail:289238516@qq.com;通信作者:侯小涛,教授,研究方向为中药活性成分与质量控制,E-mail:xthou@126.com。
