摘要
目的:探讨老年抑郁伴认知障碍的患者应用奥拉西坦胶囊与黛力新或舍曲林联合治疗的疗效。方法:选择老年抑郁伴认知障碍的患者42例,均采用奥拉西坦胶囊与黛力新或舍曲林方案治疗,观察临床效果。结果:相较治疗前,治疗后老年抑郁伴认知功能障碍患者MoCA评分明显升高,差异有统计学意义(P<0.05)。相较治疗前,治疗后患者日常生活活动能力评分BI明显升高,差异有统计学意义(P<0.05)。相较治疗前,治疗后患者NIHSS评分明显降低,差异有统计学意义(P<0.05)。42例患者经用药治疗,临床控制14例,占33.3%;显效15例,占35.7%;有效12例,占28.6%,无效1例,占2.4%,总有效率为97.6%。本次所选病例仅头晕1例,不良反应率为2.4%,无其他严重不良事件发生。结论:针对临床所选择的老年抑郁伴认知障碍的患者,应用奥拉西坦胶囊与黛力新或舍曲林联合方案治疗,可显著提高日常生活活动能力,改善认知功能,降低神经功能缺损程度,获得理想的治疗效果,且具较高安全性,故具非常重要的应用价值,值得广泛推广。
Objective To investigate the therapeutic effect of olasetam capsule combined with dielexin or shecrin in elderly patients with depression and cognitive impairment.Method 42 cases of elderly patients with depression and cognitive impairment were admitted to our hospital.All patients were treated with olasitam capsule and dalixin or sheculin to observe clinical effects.Results The MoCA score of the elderly patients with depression and cognitive dysfunction was significantly higher after treatment than before treatment.The difference was statistically significant(P<0.05).Compared with before treatment,BI of patients′daily living ability scores increased significantly after treatment,with statistical significance(P<0.05).Compared with before treatment,the NIHSS score of patients after treatment decreased significantly,the difference was statistically significant(P<0.05).Of the 42 patients selected in this group,14 cases(33.3%)were clinically controlled,15 cases(35.7%)were markedly effective,12 cases(28.6%)were effective,1 case(2.4%)was ineffective,and the total effective rate was 97.6%.Only 1 cases of dizziness were selected,the adverse reaction rate was 2.4%,no other serious adverse events occurred.Conclusion Oxiracetam capsule combined with Deanxit or sertraline can significantly improve the activity of daily living,cognitive function,reduce the degree of neurological impairment,and obtain ideal therapeutic effect for senile depression patients with cognitive impairment.Very important application value,it is worth popularizing widely.
作者
廖志东
LIAO Zhi-dong(The First People′s Hospital of Qinzhou,Qinzhou 535000,China)
出处
《吉林医学》
CAS
2019年第12期2787-2788,共2页
Jilin Medical Journal
关键词
老年
抑郁
认知障碍
奥拉西坦胶囊
黛力新
舍曲林
Old age
Depression with cognitive impairment
Oxiracetam Capsules
Deanxit
Sertraline
