摘要
子痫前期属于妊娠期高血压疾病的一种,是妊娠期特有的疾病,严重影响母婴结局,其发病机制尚未研究明确。研究表明,基质金属蛋白酶与子痫前期的发病机制有关,主要参与子痫前期的滋养细胞侵袭异常、内皮细胞功能障碍、血管生成失衡等过程。本文综述了基质金属蛋白酶在子痫前期中作用的研究现状,为进一步研究子痫前期的病因提供理论依据。
Preeclampsia is a kind of hypertensive disorders complicating pregnancy,which is a special disease in pregnancy and seriously affects maternal and infant outcomes.Its pathogenesis has not been clearly clarified.Studies have shown that matrix metalloproteinases are related to the pathogenesis of preeclampsia,and are mainly involved in the processes of abnormal trophoblast cell invasion,endothelial cell dysfunction,and imbalance of angiogenesis in preeclampsia.In this paper,the role of matrix metalloproteinase in preeclampsia was reviewed,which provided theoretical basis for further study on the etiology of preeclampsia.
作者
许晓红
关红琼
XU Xiao-hong;GUAN Hong-qiong(Department of Obstetrics,the Second Affiliated Hospital of Hainan Medical University,Haikou 570226,Hainan,CHINA)
出处
《海南医学》
CAS
2019年第22期2981-2984,共4页
Hainan Medical Journal
关键词
子痫前期
妊娠期高血压疾病
基质金属蛋白酶-2
基质金属蛋白酶-9
细胞外基质
Preeclampsia
Hypertensive disorders complicating pregnancy
Matrix metalloproteinase-2
Matrix metalloproteinase-9
Extracellular matrix
作者简介
通讯作者:关红琼,主任医师,硕士,研究生导师,E-mail:guanhq@163.com。
