摘要
目的观察奥氮平与氯氮平治疗难治性精神分裂患者的临床疗效分析奥氮平的药理学作用。方法选取自2017年1月至2018年1月于沈阳市精神卫生中心收治的难治性精神分裂症患者50例,采用信封法随机分为试验组和对照组,其中对照组25例,采用氯氮平口服,试验组25例,采用口服奥氮平,应用PANSS量表观察两组患者的疗效,应用TESS量表观察两组患者的不良反应。结果试验组患者的有效率与对照组比较差异无统计学意义(P>0.05),不良反应方面对照组发生率大于对照组,比较有统计学差异(P<0.05)。结论奥氮平与氯氮平治疗难治性精神分裂患者都具有良好的临床疗效,但是奥氮平不良反应较氯氮平轻。
Objective To observe the clinical efficacy of olanzapine and clozapine in the treatment of refractory schizophrenia.Methods 50 patients with refractory schizophrenia admitted from January 2017 to January 2018 in Shenyang mental health center were randomly divided into experimental group and control group by the envelope method.25 cases in the control group were treated with clozapine,25 cases in the experimental group,orally oranzapine,and the PANSS scale was used to observe the treatment of two groups.The TESS scale was used to observe the side effects of the two groups.Results There was no significant difference between the experimental group and the control group(P>0.05),and the incidence of the side effects in the control group was greater than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Olanzapine and clozapine both have good clinical effects in the treatment of refractory schizophrenia,but the side effect of olanzapine is clozapine.
作者
薛文达
XUE Wen-da(Department of Pharmaceutical Machinery,Shenyang Mental Health Center,Shenyang 110168,China)
出处
《中国医药指南》
2019年第30期4-4,8,共2页
Guide of China Medicine
