摘要
近年,抗精神分裂症药物联合使用有日益增加的趋势。本文现对氯氮平、奥氮平与其他抗精神分裂药物联合使用的疗效与安全性作一简要回顾。氯氮平和舒必利联用有较肯定的疗效,但可致血清催乳素水平升高或锥体外系反应加剧。氯氮平和氨磺必利联用患者病情似可全面改善,但可致血清催乳素水平升高。氯氮平和利培酮联用的临床疗效和安全性试验显示不同的结果。奥氮平和其他某些典型抗精神病药联用治疗效果有所增强。奥氮平与利培酮联用似有助于改善难治性精神分裂症患者症状。笔者认为应对这些联用的利弊作进一步的评估,以利于合理安全用药。
There is an increasing tendency for combined use of antischizophrenic drugs in recent years. This paper now briefly reviews the efficacy and safety to elozapine or olanzapine combined with other antischizophrenic drugs. Clozapine in combination with sulpiride is relatively definite in efficacy, hut it may eanse increased serum prolactin level or aggravated extrapyramidal disorders. Clozapine combined with amisulpride seems to be effective in complete improvement of patients ＇ condition, but increased serum prolactin level may occur. Clinical trials for efficacy and safety of clozapine in combination with risperidone show different results： Olanzapine combined with some other classical antipsychotic drugs may increase some degree of therapeutic effects. Olanzapine in combination with risperidone appear to be beneficial to improvement of symptoms in patients with refractory schizophrenia. The author considers that the benefit and risk of the combinations mentioned above should be evaluated further in order to benefit to rational and safe use of the drugs.
出处
《药物不良反应杂志》
2009年第2期106-110,共5页
Adverse Drug Reactions Journal
