摘要
目的探讨不同放射治疗分割方式对脑转移瘤患者放疗后的影响。方法选取放射治疗的脑转移瘤患者60例,按照随机数字表法分为甲组(常规剂量分割方式)和乙组(低剂量分割方式),每组30例。甲组采用全脑放疗2周,照射剂量(DT)为30 Gy,分10次;局部推量1周,10 Gy,分5次。乙组采用全脑放疗4周,DT为40 Gy,分20次;局部推量1周,10 Gy,分5次。治疗结束后观察两组临床疗效、卡氏(KPS)评分,放疗不良反应及精神障碍情况,中位生存期及血清S-100β蛋白水平。结果甲组精神障碍发生率为60.0%,高于乙组的10.0%;且放疗后1、5、14 d的血清S-100β蛋白水平高于乙组,差异有统计学意义(P<0.05)。甲组总有效率为26.7%,高于乙组的60.0%;且中位生存期为8.3个月,短于乙组的11.2个月,差异有统计学意义(P<0.05)。结论脑转移瘤患者应用低剂量分割方式,其临床疗效较好,精神障碍发生率少,值得推广应用。
Objective To investigate the effect of different radiotherapy segmentation methods after radiotherapy in the patients with brain metastasis.Methods Sixty patients with brain metastasis treated by radiotherapy were selected and divided into the group A(conventional dose segmentation mode)and B(low dose segmentation mode)according to the random number table,30 cases in each group.The group A adopted the whole brain radiotherapy for 2 weeks,and the dose of radiation(DT)was 30 Gy,10 times;the local push amount was for 1 week,10 Gy,5 times.The group B adopted the whole brain radiotherapy for 4 weeks,DT was 40 Gy,20 times;local push amount was 1 weeks,10 Gy,5 times.After the treatment end,the clinical efficacy and physical fitness score(KPS)of the two groups were observed.The adverse reactions and mental disorders of radiotherapy,median survival time and serum S-100βprotein level were observed.Results The incidence rate of mental disorders in the group A was 60.0%,which was higher than 10.0%in the group B;moreover the serum S-100βprotein levels on 1,5,14 d after radiotherapy in the group A were higher than those in the group B,and the differences were statistically significant(P<0.05).The total effective rate in the group A was 26.7%,which was higher than 60.0%in the group B,moreover the median survival time was 8.3 months,which was shorter than 11.2 months in the group B,the difference was statistically significant(P<0.05).Conclusion Adopting the low dose segmentation mode in the tumor patients with brain metastasis is good,and the incidence of mental disorders is low,which is worthy of popularization and application.
作者
徐雄健
程祖胜
王亮
冯江峰
张群峰
XU Xiongjian;CHENG Zusheng;WANG Liang;FENG Jiangfeng;Zhang Qunfeng(Department of Radiology,Shaoxing Municipal Seventh People's Hospital,Shaoxing,Zhejiang 312000,China;Department of Radiology,Affiliated Hospital,Shaoxing College of Arts and Sciences,Shaoxing,Zhejiang 312000,China;Department of Radiology,Shaoxing Municipal People's Hospital,Shaoxing,Zhejiang 312000,China;Department of Radiology,Wuxing District Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Huzhou,Zhejiang 313000,China)
出处
《重庆医学》
CAS
2019年第22期3862-3865,共4页
Chongqing medicine
关键词
放射治疗
分割方式
脑转移
精神障碍
radiotherapy
segmentation mode
brain metastasis
mental disorders
作者简介
徐雄健(1990-),主治医师,本科,主要从事医学影像方面工作。
