摘要
对18例上消化道癌前病变患者的舌苔和其自留地土壤真菌测序,进行菌群α、β多样性及菌群结构分析,并采用Spearman秩相关分析两者之间的相关性.上消化道癌癌前病变(PLUG)患者舌苔真菌丰富度指数(1.67±2.79)、多样性指数(0.25±0.10)均低于自留地土壤的真菌丰富度指数(4.00±4.69)和多样性指数(0.99±0.18)(P值均<0.001);PLUG患者舌苔中11个真菌分类单元的相对丰度与土壤存在正相关(P值均<0.05).
The fungal microbiota from self-retained soil and tongue coating of 18 patients with precancerous lesions of upper gastrointestinal (PLUG) were sequenced. The diversity of α, β in and the structure of the microbial community were analyzed, and the association of them was quantified by using the Spearman rank correlation method. The richness index (1.67±2.79) and the diversity index (0.25±0.10) of the fungal microbiota from tongue coating of PLUG patients were significantly lower than those from soil (4.00± 4.69;0.99±0.18) (all P values<0.001). The relative abundance of 11 taxa from tongue coating of these PLUG patients was positively associated with that from soil (all P values<0.05).
作者
华召来
孙娴
王晨怡
陆斌
徐硕
向春婕
张军峰
魏文强
Hua Zhaolai;Sun Xian;Wang Chenyi;Lu Bin;Xu Shuo;Xiang Chunjie;Zhang Junfeng;Wei Wenqiang(Yangzhong Cancer Institute,People′s Hospital of Yangzhong City,Yangzhong 212200,China;Medical School,Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of oncology,People′s Hospital of Yangzhong City,Yangzhong 212200,China;Cancer Registry Office,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2019年第11期1166-1169,共4页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金(81473458,81473593)
国家重点研发计划(2016YFC0901404)
镇江市重点研发社会发展项目(SHW2016024)
镇江市卫生计生科技重点专项(SHW2017025)。
关键词
癌前状态
舌
土壤
真菌
病例对照研究
Precancerous conditions
Tongue
Soil
Fungi
Case-control studies
作者简介
通信作者:张军峰,Email:zhangjunfeng5_5@163.com,电话:025-85811925;通信作者:魏文强,Email:weiwq@cicams.ac.cn,电话:010-87788661。
