摘要
目的评价静脉输注硫酸镁对甲状腺手术女性患者术后早期恢复质量的影响.方法选择择期行甲状腺手术的女性患者80例,年龄20~65岁,BMI 18~30 kg/m^2,ASA分级Ⅰ或Ⅱ级.采用随机数字表法将患者分为两组(每组40例):硫酸镁组(M组)和对照组(C组).两组均采用常规全身麻醉,气管插管后,M组静脉输注硫酸镁负荷量50 mg/kg(注射时间15 min),后以15 mg·kg^-·1 h^-1的速度维持至术毕.C组输注等容量的生理盐水.分别于术前1 d(T1)、术后1 d(T2)和术后2 d(T3)采用40项恢复质量评分量表(40-item Quality of Recovery Questionnaire,QoR-40量表)评价患者的恢复质量.记录瑞芬太尼用量、反应时间、拔管时间、入PACU时VAS评分、补救镇痛发生情况、恶心呕吐发生情况和PACU停留时间.结果与C组比较,M组患者瑞芬太尼用量减少[(0.065±0.018)μg·kg^-1·min^-1比(0.085±0.022)μg·kg^-1·min^-1],入PACU时VAS评分降低[1(1,2)比2(1,4)],T2、T3时身体舒适度、情绪状态、疼痛评分及总评分升高(P<0.05).两组患者的反应时间、拔管时间、补救镇痛发生情况、恶心呕吐发生情况和PACU停留时间比较,差异无统计学意义(P>0.05).结论静脉输注硫酸镁可改善甲状腺手术女性患者术后早期恢复质量.
Objective To evaluate the effects of intravenous administration of magnesium sulfate on the early recovery of female patients after thyroid surgery.Methods Eighty female patients,aging 20-65 y,with body mass index(BMI)18-30 kg/m^2,American Society of Anesthesiologists(ASA)grades Ⅰ or Ⅱ,scheduled for thyroid surgery,were enrolled in this study.They were randomly divided into two groups(n=40):a magnesium sulfate group(group M)or a control group(group C).All patients received general anesthesia.Immediately after intubation,magnesium sulfate was intravenously administered at 50 mg/kg for 15 min,followed by 15 mg·kg^-1·h^-1 to the end of surgery.Group C received an equivalent volume of normal saline.The quality of recovery was assessed using the 40-item Quality of Recovery Questionnaire(QoR-40)scale one day before surgery(T1),and one day after surgery(T2)and two days after surgery(T3).The remifentanil consumption,response time,extubation time,the Visual Analogue Scale(VAS)score when entry into post-anesthesia care unit(PACU),the use of rescue analgesia,the incidence of nausea and vomiting,and PACU stay were recorded.Results Compared with group C,the remifentanil consumption[(0.065±0.018)μg·kg^-1·min^-1 vs(0.085±0.022)μg·kg^-1·min^-1]and VAS score at the time of arrival to PACU[1(1,2)vs 2(1,4)]were decreased,the physical comfort,emotional state,pain scores and global QoR-40 score in T2,T3 were increased in group M(P<0.05).There was no statistical difference between two groups in the response time,extubation time,incidence of rescue analgesia,incidence of postoperative nausea and vomiting and time of PACU stay(P>0.05).Conclusions Intravenously administered magnesium sulfate can improve the female patients′quality of recovery during early period after thyroid surgery.
作者
刘春宏
胡庆波
王中清
刘夏曦
尹利群
Liu Chunhong;Hu Qingbo;Wang Zhongqing;Liu Xiaxi;Yin Liqun(Department of Anesthesiology,Huainan Chaoyang Hospital,Huainan 232007,China)
出处
《国际麻醉学与复苏杂志》
CAS
2019年第9期852-855,共4页
International Journal of Anesthesiology and Resuscitation
关键词
硫酸镁
甲状腺手术
女性
恢复质量
Magnesium sulfate
Thyroid surgery
Female
Quality of recovery
作者简介
通信作者:刘春宏,Email:ycw424@163.com。
