摘要
目的探讨MR平扫和增强在异柠檬酸脱氢酶-1(IDH1)突变阳性或阴性脑胶质瘤诊断中的价值。方法回顾性分析92例经病理确诊的脑胶质瘤患者术前MRI影像表现,分析IDH1突变阳性(IDH1突变阳性组)和阴性(IDH1突变阴性组)胶质瘤病变部位、信号、边界、生长模式、强化程度及瘤周水肿及程度的差异,并建立二分类Logistic模型。结果 2组不同级别胶质瘤及脑内病灶分布差异均有统计学意义(P均<0.05)。2组肿瘤信号、边界和生长模式差异无统计学意义(P=0.269、0.606、0.139),强化程度和瘤周水肿及程度差异均有统计学意义(P均<0.01)。经Logistic回归分析发现,脑胶质瘤的信号均匀性(X1)、边界(X2)及强化程度(X3)差异有统计学意义(P=0.004、0.037、0.001),回归方程为:logit(P)=2.668+1.415X1-2.097X2-3.229X3(χ2=41.583,P<0.001),模型的敏感度为70.70%,特异度为80.40%。结论 MR平扫和增强扫描可清晰显示IDH1突变阳性和阴性脑胶质瘤的影像学特征,为脑胶质瘤IDH1突变状态的术前预测提供无创的影像学手段。
Objective To observe the value of MR in prediction of glioma isocitrate dehydrogenase(IDH) 1 mutation status. Methods Nineteen-two patients with glioma were divided into IDH mutation positive group and negative group, and their imaging characteristics were retrospectively reviewed, including lesions’ site, signal intensity, boundary, growth pattern, degree of enhancement and surrounding edema. Then two-class Logistic model was established. Results There were significant differences between different grades and location of gliomas between the two groups(both P<0.05). There were no significant differences in tumor signal intensity, boundary and growth pattern(P=0.269, 0.606, 0.139). There were statistically significant difference in degree of enhancement and surrounding edema(all P<0.01). Logistic regression analysis showed that the signal uniformity(X1), boundary(X2) and degree of enhancement(X3) of gliomas were statistically significant(P=0.004, 0.037, 0.001), and the regression equation was: logit(P)=2.668+1.415X1-2.097X2-3.229X3(χ2=41.583, P<0.001), the sensitivity of the model was 70.70%, and the specificity was 80.40%. Conclusion MRI can be used to non-invasively predict IDH1 mutation status of gliomas before surgical operation.
作者
宋双双
於帆
闫新亭
朴月善
徐建堃
卢洁
SONG Shuangshuang;YU Fan;YAN Xinting;PIAO Yueshan;XU Jiankun;LU Jie(Department of Radiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China;Department of Pathology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
出处
《中国医学影像技术》
CSCD
北大核心
2019年第11期1632-1637,共6页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金优秀青年科学基金(81522021)
北京市医院管理局“登峰”计划专项经费(DFL20180802)
关键词
脑
胶质瘤
异柠檬酸脱氢酶1
磁共振成像
分子亚型
brain
gliomas
isocitrate dehydrogenase 1
magnetic resonance imaging
molecular subtypes
作者简介
第一作者:宋双双(1992—),女,山东青岛人,在读博士。研究方向:影像诊断。E-mail:song2222shuang@163.com;通信作者:卢洁,首都医科大学宣武医院放射科,100053;磁共振成像脑信息学北京市重点实验室,100053;首都医科大学宣武医院核医学科,100053。E-mail:imaginglu@hotmail.com。
