摘要
目的探讨重组人干扰素α-2b雾化吸入治疗毛细支气管炎的临床疗效与相关的护理配合方法。方法选取蚌埠医学院第一附属医院2017年11月-2018年11月收治的毛细支气管炎患儿120例,采用随机数字表法进行分组,分为对照组60例和观察组60例。对照组采用吸入用布地奈德混悬液+0.9%氯化钠(1 mL)治疗;观察组采用吸入用布地奈德混悬液与重组人干扰素α-2b联合雾化吸入治疗。分析2组患儿临床症状改善时间及住院时间,比较2组治疗效果及不良反应情况。结果观察组总有效率为91.7%,对照组总有效率为73.8%,2组比较差异有统计学意义(P<0.05);治疗后观察组喘息消失时间为(4.82±0.93)d,咳嗽消失时间为(2.85±0.76)d,肺部啰音消失时间为(6.12±0.96)d,住院时间为(7.65±1.36)d;对照组喘息消失时间为(5.37±0.12)d,咳嗽消失时间为(3.42±1.14)d,肺部啰音消失时间为(6.73±1.13)d,住院时间为(8.43±1.52)d,2组比较差异均有统计学意义(P<0.05)。结论重组人干扰素α-2b雾化吸入治疗毛细支气管炎患儿,配合有效的护理措施,能明显改善患儿临床症状,缩短住院时间。
Objective To study the clinical observation and nursing effect of recombinant human interferon α-2 b injection in the treatment of bronchitis capillarity by atomization inhalation.Methods We selected 120 cases of children with bronchitis in the First Hospital of Bengbu Medical College and grouped them by random numerical tables.The control group(n=60)was treated with inhalation budesonide suspension+0.9%sodium chloride 1 mL.The observation group(n=60)was treated with inhalation budesonide suspension combined with recombinant human interferonα-2 b atomization inhalation.The two groups of treatment effect,adverse reactions,analysis of two groups of clinical symptom improvement time and hospitalization time were compared.Results The total efficiency of the observation group was higher than that of the control group by 91.7%to 73.8%,and the difference was statistically significant(P<0.05).After treatment,the disappearance time of wheezing was(4.82±0.93)days,the disappearance time of coughing was(2.85±0.76)days,the disappearance time of pulmonary rales was(6.12±0.96)days,and the length of hospitalization was(7.65±1.36)days in the observation group.In the control group,the disappearance time of wheezing was(5.37±0.12)days,the disappearance time of coughing was(3.42±1.14)days,the disappearance time of lung rashes was(6.73±1.13)days,and the length of hospitalization was(8.43±1.5)days,all of which were statistically significant(P<0.05).Conclusion The combination of recombinant human interferonα-2 b atomization inhalation for children with bronchitis can effectively improve symptoms,reduce hospitalization time,and have fewer adverse reactions and safety.
作者
方姗姗
荣道香
刘继秀
彭万胜
周瑞
FANG Shan-shan;RONG Dao-xiang;LIU Ji-xiu(Department of Pediatrics,the First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233004,China)
出处
《中华全科医学》
2019年第11期1954-1956,共3页
Chinese Journal of General Practice
基金
国家卫生计生委医药卫生科技发展研究中心项目(W2016EWAH06)
作者简介
通信作者:周瑞,E-mail:1176034941@qq.com。
