摘要
目的研究急性脑梗死(ACI)患者NT-proBNP、Hcy及D-D水平变化及其与神经损伤的关系。方法选取本院收治的ACI患者120例设为ACI组,根据NIHSS评分将其分为A组(62例,NHISS评分<4分)、B组(36例,NHISS评分4~15分)及C组(22例,NIHSS评分>15分)。另选取同期入院体检的健康志愿者60例作为对照组。比较各组之间NT-proBNP、Hcy、D-D水平,分析上述指标与NHISS评分之间的关系。结果ACI组的NT-proBNP、Hcy、D-D水平显著高于对照组(P<0.05)。A组患者的NT-proBNP、Hcy、D-D水平明显低于B组和C组(P<0.05);B组NT-proBNP、Hcy、D-D水平明显低于C组(P<0.05)。NT-proBNP、Hcy、D-D水平与NIHSS评分呈正相关(P<0.05)。结论NT-proBNP、Hcy、D-D水平变化与ACI患者的病情发生发展、神经损伤关系密切,可将NT-proBNP、Hcy、D-D作为临床检验中评估ACI的有效指标。
Objective To study the changes of NT-proBNP,Hcy and D-D levels in patients with acute cerebral infarction(ACI)and their relationship with nerve injury.Methods A total of 120 patients with ACI admitted in our hospital were selected as ACI group.According to NIHSS score,patients were divided into group A(62 cases,NHISS score<4 points),group B(36 cases,NHISS score of 4-15 points)and group C(22 cases,NIHSS score>15 points).Another 60 healthy volunteers were selected as control group.The levels of NT-proBNP,Hcy and D-D were compared among the groups,and the relationship between the above indicators and NHISS score were analyzed.Results The levels of NT-proBNP,Hcy and D-D in the ACI group were significantly higher than those in the control group(P<0.05).The levels of NT-proBNP,Hcy and D-D in the group A were significantly lower than those in the group B and C(P<0.05);the levels of NT-proBNP,Hcy and D-D in the group B were significantly lower than those in the group C(P<0.05).The levels of NT-proBNP,Hcy and D-D were positively correlated with NIHSS scores(P<0.05).Conclusion The changes of NT-proBNP,Hcy and D-D levels are closely related to the occurrence and development of ACI and nerve injury.NT-proBNP,Hcy and D-D can be used as effective indicators to evaluate ACI in clinical tests.
作者
高洁
吕静
王禺
GAO Jie;LYU Jing;WANG Yu(Clinical Laboratory Department,Xi'an No.1 Hospital,Xi'an 710000,China)
出处
《临床医学研究与实践》
2019年第30期36-37,共2页
Clinical Research and Practice
基金
陕西省科学技术研究发展计划项目(No.2015SF229)
作者简介
高洁(1981-),女,汉族,陕西西安人,主管检验技师,学士。研究方向:医学检验;通讯作者:吕静,E-mail:lvjingxa@126.com.
