摘要
代谢组学通过对生物体内代谢物进行高通量分析,探索代谢物与机体生理、病理变化相关性,阐明机体复杂体系相互作用及对外界响应。代谢组学强调生物体整体研究功能状态的生化表型与中医理论的整体观具有高度相似性,以其独特的整体、动态的表达特征与中医药的整体观、辨证论治的诊疗思维不谋而合。应用代谢组学技术阐明中医药有效性相关效应机制、物质基础、配伍规律等科学问题,使中医传统理论与现代科学技术有机融合,可充分理解中医理论科学价值及中医临床经验实用价值。本文探讨将代谢组学的整体性、动态性等研究特色应用到中医药具体实践,解决中药材效应评价、复方配伍规律阐释、中医方证关系研究、证候生物标志物发现等关键问题,为中药有效性评价、复方物质基础以及中医证候本质认识提供技术支持。
Metabolomics could explore the correlation between metabolites and physiological and pathological changes through high-throughput analysis of metabolites in the body,and clarify the interaction of complex systems and response to the outside body.Metabolomics emphasizes that the biochemical phenotype of the functional state of the organism as a whole that is highly similar to the holistic view of traditional Chinese medicine(TCM)theory.Metabolomics has its unique overall and dynamic expression characteristics coincides with the overall view of Chinese medicine and dialectical treatment diagnosis.The metabolomics technology is used to clarify the scientific effects related to the effectiveness mechanism,material basis and compatibility of TCM,to realize the organic integration of TCM theory and modern life science and technology,and fully understand the theoretical value of TCM theory and the practical value of TCM clinical experience.This paper explores the application of the holistic and dynamic characteristics of metabolomics to the specific practice of TCM,and solves key problems,such as the effect evaluation of Chinese herbal medicine,the interpretation of prescription compatibility,the relationship research of prescription and syndrome,and the discovery of syndrome biomarkers.It will provide the technical support for the evaluation of the effectiveness of TCM,the basis of prescription substances and the understanding essence of TCM syndromes.
作者
杨波
杨强
张爱华
王喜军
YANG Bo;YANG Qiang;ZHANG Aihua;WANG Xijun(National Research Center of Traditional Chinese Medicine Metabolism,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)
出处
《中国医药导报》
CAS
2019年第24期24-28,共5页
China Medical Herald
基金
国家自然科学基金重点项目(81430093)
国家自然科学基金重点项目(81830110)
关键词
中医药
代谢组学
生物标志物
证候
方证代谢组学
Traditional Chinese medicine
Metabolomics
Biomarker
Syndrome
Chinmedomics
作者简介
通讯作者:王喜军(1961-),男,博士,教授,博士生导师;研究方向:中药血清药物化学及中医方证代谢组学研究。
