摘要
以心得舒作为归巢装置导向脂质体分布于富含β受体的组织器官。结果表明,应用这种心得舒脂质体携载还原型谷胱甘肽,能有效地治疗异丙基肾上腺素引起的大鼠心肌缺血坏死。提示,受体配基作为归巢装置是增强脂质体特异靶向性的有效方法。
In order to investigate feasibility of applying receptor ligand as homing devices to potentiatetargeting of liposome carried drugs. we observed tissue distribution characteristics of alprenolol-liposome containing glutathione on isoproterenol (ISO)-induced rat myocardial necrosis. The resultsshowed alprenolol altered liposome distrubution in vivo and led the liposome to distribute tissues andorgans rich in β-receptors, such as lung and heart. This alprenolol-liposome encapsulated with gluta-thione showed effectively therapeutic action on ISO-induced rat myocardial necrosis. The resultssuggest that use of receptor ligand as homing device is a method of powerfully potentiating specifictargeting of liposome.
出处
《北京医科大学学报》
CSCD
1992年第5期360-362,共3页
Journal of Peking University(Health Sciences)
