摘要
以过碘酸钠为氧化剂对海藻酸钠进行了氧化改性,以期改善其的降解性能。红外光谱结果表明,海藻酸钠经氧化后生成了活性醛基。适宜氧化度的氧化海藻酸钠在模拟生理条件下降解速率较快,在37℃、pH=7.4的PBS溶液中降解100 h即达到平台期,分子量从初始的11.2×104g/mol降至3.6×104g/mol。与原始海藻酸盐水凝胶相比,氧化海藻酸盐水凝胶强度随时间呈明显下降趋势。当氧化剂量达到一定程度时,由于分子结构遭到严重破坏,氧化海藻酸钠不形成凝胶。
Sodium alginate has been widely used in a itself has a very slow degradation rate, and its gels variety of biomedical apphcations. However, alginate degrade in an uncontrollable manner, releasing high molecular weight strands that are difficult to drain from the body. In order to improve the biodegradability of alginate , commercially available high molecular weight alginate was oxidized with sodium periodate. The IR analysis confirmed the characteristic peak of aldehyde group in the oxidized alginate. Oxidized alginate fully degraded at physiological condition（37 ℃, pH = 7.4 PBS） after 100 h incubation and the molecular weight reduced from 11. 2 × 10^4 g/mol to 3.6 × 10^4 g/mol. When small amounts of uronate groups were oxidized, the aqueous solution of the oxidized alginates still formed hydrogels in the presence of calcium ions in a manner similar to that of native sodium alginate. However, the compressive strengths of these hydrogels were lower than those of unmodified alginate and decreased quickly with incubation time.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第9期1007-1011,共5页
Chinese Journal of Applied Chemistry
关键词
海藻酸钠
氧化
降解
水凝胶
sodium aiginate, oxidation, degradation, hydrogel
作者简介
通讯联系人：尹玉姬，女，1969年生，副教授；E-mail：yinyuji@tju．edu．cn；研究方向：生物材料和组织工程材料
