摘要
以高脂膳食大鼠为研究对象,研究小麦糊粉层对大鼠血脂水平及胰岛素抵抗的影响。灌胃5周,结果表明小麦糊粉层可以明显减缓高脂膳食大鼠体质量增加(P<0.05)和食物摄入量。血清甘油三酯(TC)、总胆固醇(TG)和低密度脂蛋白(LDL-C)的水平显著降低,高密度脂蛋白(HDL-C)水平显著升高(P<0.05);同时血脂比值TC/HDL-C、TG/HDL-C、LDL-C/HDL-C、动脉硬化指数(AI)水平得到改善。大鼠空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)(P<0.05)、胰岛素敏感指数(ISI)和胰岛β细胞功能指数(HOMA-β)显著降低(P<0.05),总超氧化物歧化酶(T-SOD)水平显著升高(P<0.05),高脂膳食大鼠胰岛素抵抗得到缓解。小麦糊粉层剂量组肝体比明显降低,肝脏脂肪堆积明显减少。研究结果表明,小麦糊粉层干预高脂膳食,可起到降低血脂、缓解胰岛素抵抗、改善肝脏脂肪堆积的作用。
The effects of wheat aleurone layer on blood lipid level and insulin resistance in rats with highfat diet were studied.The rats were administered by gavage with aleurone layer for 5 successive weeks. Compared with the control group,the rats in the wheat aleurone layer group were significantly reduced in weight gain (P<0.05) and the food intake was also reduced.Serum levels of TC,TG and LDL-C were significantly decreased,while HDL-C significantly increased (P<0.05).Meanwhile,the blood lipid ratio TC/ HDL-C,TG/HDL-C,LDL-C/HDL-C and AI levels were improved.Serum FBG,HOMA-IR (P<0.05),ISI,and HOMA-β index were significantly reduced while T-SOD levels increased significantly (P<0.05) by aleurone layer intervention,which could alleviate insulin resistance in rats with high-fat diet.The liver body ratio and liver fat accumulation with wheat aleurone layer intervene was significantly reduced.The results showed that aleurone layer can interfere with high-fat diet,play a role in reducing blood lipid,alleviating insulin resistance,improving liver fat accumulation,and reduce the occurrence of related diseases.
作者
朱晓振
孟现尧
贾晨晨
超博
范文勇
李昕芮
吴亮
衣悦涛
ZHU Xiaozhen;MENG Xianyao;JIA Chenchen;CHAO Bo;FAN Wenyong;LI Xinrui;WU Liang;YI Yuetao(Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai 264003;University of Chinese Academy of Sciences,Beijing 100049;Binzhou Medical University,Yantai 264003;Shandong Zhishifang Food Technology Co.,LTD.,Tai'an 271024)
出处
《食品科技》
CAS
北大核心
2019年第8期163-168,共6页
Food Science and Technology
基金
中国科学院STS重点项目(KFJ-STS-ZDTP-023)
关键词
小麦糊粉层
高脂膳食
血脂
胰岛素抵抗
大鼠
wheat aleurone layer
high-fat diet
blood lipids
insulin resistance
rats
作者简介
朱晓振(1992-),男,博士研究生,研究方向为海岸带资源化学;通信作者:衣悦涛.
