摘要
目的探讨尿白蛋白/肌酐比值(albumin/creatinineratio,ACR)与原发性高血压患者临床特征的关系。方法317例原发性高血压患者根据尿ACR分为观察组(尿ACR>30mg/g)67例和对照组(尿ACR≤30mg/g)250例,比较2组临床资料,分析尿ACR水平与原发性高血压临床指标的关系,采用Spearman和Pearson相关分析尿ACR水平与原发性高血压临床指标的相关性。结果与对照组比较,观察组患者年龄较大,尿蛋白阳性率、体质量指数、并发症发生率较高,病程较长,血清白蛋白水平较低,尿ACR、血清三酰甘油、血肌酐、血尿素氮、血尿酸、血糖及血清胱抑素C水平较高(P<0.05);高血压分级越高、病程越长患者尿ACR水平越高(P<0.05),有并发症者尿ACR水平[12.4(6.2,47.8)mg/g]高于无并发症者[7.4(4.5,14.4)mg/g](P<0.05);原发性高血压患者尿ACR水平与高血压分级(r=0.198,P<0.001)、体质量指数(r=0.141,P<0.037)、病程(r=0.215,P<0.001)、血尿素氮(r=0.210,P=0.003)、血尿酸(r=0.214,P=0.002)及血清胱抑素C水平(r=0.225,P=0.002)呈正相关,与血清白蛋白水平呈负相关(r=-0.191,P=0.007)。结论尿ACR是监测原发性高血压患者疾病进展的关键因素,定期检测尿ACR对原发性高血压早期肾损伤有重要的诊断价值。
Objective To investigate the correlation between urinary albumin/creatinine ratio(ACR) and clinical characteristics of primary hypertension. Methods Totally 317 patients with primary hypertension were divided into 67 patients with ACR>30 mg/g(observation group) and 250 patients with ACR≤30 mg/g(control group). The clinical data were collected and the relationship between urinary ACR and clinical indexes was analyzed. Spearman and Pearson correlation coefficients were adopted to analyze the correlation between urinary ACR level and clinical indexes of primary hypertension. Results Compared with control group, observation group has older age, longer course of disease, lower serum albumin level, and higher urinary ACR, urinary ACR, positive rate of urinary protein, body mass index, complication rate, serum triacylglycerol, serum creatinine, blood urea nitrogen, serum uric acid, plasma glucose and serum cystatin C levels(P<0.05). The level of urinary ACR was higher in patients with higher grade of hypertension and longer course of hypertension(P<0.05), and was higher in patients with complications(12.4(6.2, 47.8) mg/g) than that in patients without complications(7.4(4.5, 14.4) mg/g)(P<0.05). The level of urinary ACR in patients with primary hypertension was positively correlated with hypertension grade(r=0.198, P<0.001), body mass index(r=0.141, P<0.037), course of hypertension(r=0.215, P<0.001), blood urea nitrogen(r=0.210, P=0.003), serum uric acid(r=0.214, P=0.002) and serum cystatin C(r=0.225, P=0.002), and negatively correlated with serum albumin(r=-0.191, P=0.007). Conclusion Urinary ACR is a key factor for monitoring the progression of primary hypertension and regular detection of urinary ACR has an important diagnostic value for early renal injury in patients with primary hypertension.
作者
张丽娜
杨苗苗
王雁良
李纳
曹慧霞
阎磊
邵凤民
ZHANG Lina;YANG Miaomiao;WANG Yanliang;LI Na;CAO Huixia;YAN Lei;SHAO Fengmin(Department of Nephrology , Henan Provincial Key Laboratory of Kidney Disease and Immunology,Henan Provincial People's Hospital, People's Hospital of Zhengzhou University , Zhengzhou 450003, China)
出处
《中华实用诊断与治疗杂志》
2019年第8期816-818,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金(81770725),国家自然科学基金(81700578)
关键词
高血压
尿白蛋白/肌酐比值
尿蛋白
hypertension
urinary albumin/creatinine ratio
urinary protein
作者简介
通信作者:邵凤民,E-mail:fengminshao@medmail.com.cn.
