摘要
目的 了解孕产妇病毒性肝炎血清抗原/抗体检测结果的分布特点,为进一步预防和治疗病毒性肝炎提供理论依据。方法 利用全自动免疫分析仪对北京天坛医院2014-2018年就诊的孕产妇乙型肝炎病毒相关指标进行检测,利用SPSS20.0软件对数据进行统计学分析。结果 11617例孕产妇HBsAg阳性率为0.35%,且呈逐年下降趋势,而HBsAb阳性率为63.07%,其中≥35岁高龄孕产妇HBsAb阳性率显著低于<35岁者(58.65%vs.63.74%,P<0.05)。6255例孕产妇丙型肝炎病毒(HCV)-IgG阳性率为0.54%,其中≥35岁高龄孕产妇中HCV-IgG阳性率(1.10%)显著高于<35岁组(0.45%),差异有统计学意义(P<0.05)。9542例孕产妇中甲型肝炎病毒(HAV)-IgM阳性患者2例,阳性率为0.02%。结论 孕产妇中病毒性肝炎仍存在一定的感染率,HBV和HCV的感染率较高且HBsAb阳性率仅为63.07%,应进一步重视和加强孕产妇中病毒性肝炎的防治工作。
Objective To understand the serological distribution characteristics of hepatitis virus in pregnant women,so as to provide theoretical basis for further prevention and treatment of viral hepatitis. Methods The autoimmune immunoassay analyzer was used to detect the hepatitis virus related indicators of pregnant women in Beijing Tiantan Hospital from 2014 to 2018,and the data were analyzed by SPSS20.0 software. Results The positive rates of HBsAg in 11 617 pregnant women were 0.35%,and it was decreasing year by year,while the positive rates of HBsAb was 63.07%.The positive rate of HBsAb in older pregnant women ≥35 years old was significantly lower than that in those <35 years old (58.65% vs .63.74%, P <0.05).The positive rate of hepatitis C virus (HCV)- IgG was 0.54% in 6 255 pregnant women,and the positive rate of HCV-IgG in the older pregnant women aged ≥ 35 (1.10%) was significantly higher than that in those aged <35 (0.45%),the difference was statistical significance ( P <0.05).2 of 9 452 pregnant women were HAV-IgM positive,and the positive rate was 0.02%. Conclusion There is still a certain infection rate of viral hepatitis in pregnant women.The infection rate of HBV and HCV is relatively high and the positive rate of HBsAb is only 63.07%.More attention should be paid to the prevention and treatment of viral hepatitis in pregnant women.
作者
王利娟
刘杰
王泉儿
刘志伟
康熙雄
张国军
WANG Lijuan;LIU Jie;WAN Quaner;LIU Zhiwei;KANG Xixiong;ZHANG Guojun(Department of Clinical Laboratory,Beijing Tiantan Hospital Affiliated to CapitalMedical University,Beijing 100070,China;Beijing Engineering Research Center of ImmunologicalReagents Clinical Research,Beijing 100070,China;Capital Medical University,Beijing 100069,China)
出处
《国际检验医学杂志》
CAS
2019年第17期2070-2072,2076,共4页
International Journal of Laboratory Medicine
基金
北京市自然科学基金项目(7194261)
作者简介
王利娟,女,医师,主要从事神经免疫方面的研究;通信作者:张国军,E-mail:tiantanzgj@163.com。
