摘要
老年人因生理功能减退且常同时患有多种基础疾病,容易出现药物不良事件(ADE),可能表现为一个或多个老年综合征,包括出现一系列非特异性的症状和体征,如跌倒、谵妄、头晕、失禁、睡眠障碍等,严重损害老年人的生活功能,影响其生活质量,甚至显著缩短预期寿命,使疾病诊断和治疗更加艰巨。故对老年人不适当用药进行识别与早期干预,将对降低药物使用风险、避免和减少ADE有重要意义。本文就国内外近年来研究的重点老年人潜在不适当用药(PIM)标准、多重用药和药物重整、PIM预防三个方面进行综述。
Older people are more likely to have adverse drug events(ADE)due to their decreased physiological function and often have multiple underlying diseases.ADE may manifest as one or more syndromes of the elderly,including falls,convulsions,dizziness,incontinence,sleep disorders,etc.,seriously affecting the life and behavioral abilities of the elderly,while giving harder for diagnosis and treatment.Identification and early intervention of inappropriate medication use in the elderly are important for reducing the risk of medication,avoiding and reducing ADE.In recent years,the research focuses on the potential inappropriate medication(PIM)use standards for the elderly,multiple drug use and medcation reconciliation,and PIM prevention,this article reviews these three aspects.
作者
赵丽艳
赵忠鹏
程艳芹
李明春
ZHAO Liyan;ZHAO Zhongpeng;CHENG Yanqin;LI Mingchun(Department of Pharmacy,the 401st Hospital of PLA,Shandong Province,Qingdao 266071,China;Institute of Microbiology and Epidemiology,Academy of Military Sciences,Beijing 100086,China)
出处
《中国医药导报》
CAS
2019年第21期47-50,共4页
China Medical Herald
基金
山东省自然科学基金资助项目(ZR2017MH118)
关键词
老年人
不适当用药
药物不良事件
研究进展
Elderly
Inappropriate medication
Adverse drug events
Research progress
作者简介
赵丽艳(1980-),女,博士;研究方向:抗肿瘤药物分析;通讯作者:李明春(1965-),男,硕士,主任药师,硕士研究生导师;研究方向:免疫药理学。
