摘要
目的探讨在鼻咽癌筛查中3项EB病毒抗体结合检测的临床应用价值。方法收集2017年7月至2018年6月佛山市第一人民医院经病理确诊的120例鼻咽癌患者为观察组,另外选取380例健康者为对照组,采用酶联免疫法检测衣壳抗原IgA抗体(VCA-IgA)、早期抗原IgG抗体(EA-IgG)、Rta蛋白抗体IgG(Rta-IgG),分析结果。结果观察组VCA-IgA、EA-IgG、Rta-IgG检测阳性率分别是:92.5%、52.5%、85.83%均高于对照组,P<0.05;3项抗体中VCA-IgA灵敏度最高特异性最低,EA-IgG特异性最高灵敏度最低,Rta-IgG灵敏度及特异性均高于85%;联合检测其灵敏度、特异性、准确度均高于单一检测,P<0.05。结论在鼻咽癌筛查中进行VCA-IgA、EA-IgG、Rta-IgGEB病毒抗体结合检测能够提高鼻咽癌筛查率,有助于患者尽早接受有效治疗。
Objective Studying the application value of three EB virus antibody binding tests in nasopharyngeal cancer screening.Methods Selecting 120 patients as the observation group who were confirmed by pathological diagnosis in the first people′s Hospital of Foshan from July 2016 to June 2018,and 380 healthy patients were selected as the control group.The capsid antigen lgA antibody (VCA-IgA),early antigen IgA antibody (EA-IgG) and Rta protein antibody IgG(Rta- IgG) were detected by ELISA.Results The positive rate of VCA-IgA,EA-IgG and Rta-IgG in the observation group were 92.5%,52.5% and 85.83%,respectively,which were higher than those in the control group,P <0.05.Among the three antibodies,the sensitivity of VCA-IgA was highest,EA-IgG was lowest,but the specificity of EA-IgG was highest,VCA-IgA was lowest.In addition,the sensitivity and specificity of Rta-IgG were more than 85%.The sensitivity,specificity and accuracy of combined diagnosis were all higher than that of single diagnosis,P <0.05.Conclusion Three EB virus antibodies binding tests in screening for nasopharyngeal cancer can improve the screening rate of nasopharyngeal cancer and help patients receive effective treatment as early as possible.
作者
李辉腾
黎卓华
崔敏涛
杨洁飞
陈展泽
LI huiteng;LI Zhuohu;CUI Mintao;YANG Jiefei;CHEN Zhanze(Department of Clinical Laboratory of guangdong hospital GDSD 528300,China;Department of Clinical Laboratory of First People′s Hospital of Foshan GDFS 528000,China)
出处
《国际检验医学杂志》
CAS
2019年第A01期126-129,共4页
International Journal of Laboratory Medicine
关键词
EB病毒抗体
鼻咽癌
筛查
检测
EB virus antibody
nasopharyngeal carcinoma
screening
detection
