摘要
Alzheimer's disease is a common clinical central nervous system degenerative disease. From 1906, it has not yet been clearly revealed the pathogenesis, and there are no clinically safe and effective drugs. Amyloid-beta (Aβ) cascade reaction theory is currently recognized as the pathogenesis. Aβ deposition of neurotoxicity is an important part of the pathogenesis. There are Aβ-induced inflammation of the central nervous and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death. This article summarizes the active ingredients of traditional Chinese medicine that has a protective effect on Aβ toxicity in recent years. Traditional Chinese medicine mainly through the antiapoptosis, antioxidation, and anti-inflammatory reduces Aβ production and deposition of Aβ on the protection of nerve cell injury.
Alzheimer’s disease is a common clinical central nervous system degenerative disease.From 1906,it has not yet been clearly revealed the pathogenesis,and there are no clinically safe and effective drugs.Amyloid-beta(Aβ)cascade reaction theory is currently recognized as the pathogenesis.Aβdeposition of neurotoxicity is an important part of the pathogenesis.There are Aβ-induced inflammation of the central nervous and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death.This article summarizes the active ingredients of traditional Chinese medicine that has a protective effect on Aβtoxicity in recent years.Traditional Chinese medicine mainly through the antiapoptosis,antioxidation,and anti-inflammatory reduces Aβproduction and deposition of Aβon the protection of nerve cell injury.
基金
supported by Guangxi Science and Technology Plan Project(GKH1347004-16,15-140-31,17-259-20,GKG1355004-11)
作者简介
Address for correspondence:Assoc Prof.Er-wei Hao,Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica,Guangxi University of Chinese Medicine,Nanning,Guangxi,China.E-mail:ewhao@163.com;Prof.Jia-Gang Deng,Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica,Guangxi University of Chinese Medicine,Nanning,Guangxi,China.E-mail:dengjg53@126.com
