摘要
目的:观察疏风明目方超声雾化对过敏性结膜炎患者泪膜稳定性及泪液相关指标的影响。方法:将140例过敏性结膜炎患者随机分为两组,对照组70例给予盐酸奥洛他定滴眼液联合生理盐水雾化治疗,观察组70例给予盐酸奥洛他定滴眼液联合疏风明目方超声雾化治疗。连续治疗14d后,比较两组临床疗效、治疗前后单项症状(流泪、痒感、畏光、异物感)、泪膜稳定性(BUT、FL)、泪液相关指标[嗜酸性细胞阳离子蛋白(ECP)、HA、IgE]。结果:观察组治疗后总有效率高于对照组(90.7%vs74.3%,P<0.05);两组治疗后单项症状积分均低于治疗前,且观察组均低于对照组(P<0.05);两组治疗后BUT均高于治疗前,FL均低于治疗前,且观察组改善程度均优于对照组(P<0.05);两组治疗后泪液HA、ECP、IgE水平均低于治疗前,且观察组改善程度均优于对照组(P<0.05)。结论:疏风明目方超声雾化治疗能够改善过敏性结膜炎患者泪液相关指标,提高泪膜稳定性,有助于缓解局部变态反应,改善患者临床症状。
AIM: To observe the effect of ultrasonic atomization of Shufeng Mingmu Decoction on tear film stability and index of tear fluid in patients with allergic conjunctivitis. METHODS: Totally 140 patients with allergic conjunctivitis were randomly divided into 2 groups. 70 patients in the control group were treated with olopatadine hydrochloride eye drops combined with normal saline atomization therapy, while the 70 patients in the observation group were treated with ultrasonic atomization of Shufeng Mingmu Decoction combined with oldpatadine hydrochloride eye drops. After 14d of continuous treatment, the single symptoms (lacrimation, itching, photophobia, foreign body sensation), the stability of tear film (BUT, FL), and the index of tear fluid (ECP, HA, IgE) of the two groups were compared and analyzed. The clinical effects of the two groups were compared. RESULTS: The total effective rate of the observation group was significantly higher than that of the control group (90.7% vs 74.3%, P <0.05). After treatment, the scores of single symptoms in both groups were lower than those before treatment, and those in the observation group were lower than those in the control group ( P <0.05). After treatment, the index of BUT in both groups were significantly higher than before treatment ( P <0.05), while the index of FL was significantly lower than before treatment, and the improvement degree of which in the observation group was better than that of control group ( P <0.05). After treatment, the levels of HA, ECP and IgE in the two groups were significantly lower than before treatment, and the improvement degree of which in the observation group was better than that in the control group ( P <0.05). CONCLUSION: Ultrasonic atomization treatment of Shufeng Mingmu Decoction can improve the index of tear fluid of allergic conjunctivitis patients and the stability of tear film, which help relieve local allergy and improve clinical symptoms of patients.
作者
杨森
唐建明
忽俊
黄洁
熊毅
顾春燕
Sen Yang;Jian-Ming Tang;Jun Hu;Jie Huang;Yi Xiong;Chun-Yan Gu(Shanghai Baoshan Integrated Traditional Chinese and Western Medicine Hospital, Shanghai 201900, China)
出处
《国际眼科杂志》
CAS
北大核心
2019年第6期1068-1071,共4页
International Eye Science
关键词
过敏性结膜炎
疏风明目方
超声雾化
泪膜稳定性
泪液相关指标
allergic conjunctivitis
Shufeng Mingmu Decoction
ultrasonic atomization
tear film stability
index of tear fluid
作者简介
杨森,毕业于武汉科技大学医学院,本科,主治医师,研究方向:白内障、青光眼及眼表;通讯作者:唐建明,毕业于同济大学医学院,本科,主任医师,科主任,研究方向:青光眼、白内障.13916977039@qq.com.
