摘要
目的:探究养心冠脉汤对冠脉支架植入术患者再狭窄的治疗效果,分析其对患者血清TNF-α(肿瘤坏死因子-α)和CRP(C反应蛋白)的影响。方法:选取行冠脉支架介入术治疗的患者60例,采用随机数字表法分成治疗组30例和对照组30例。对照组采用阿司匹林肠溶片、氯吡格雷片、阿托伐他汀钙片等药物治疗,治疗组在对照组的治疗基础上加用养心通脉汤口服治疗,所有患者均治疗6个月。统计两组患者再发生冠脉狭窄的比例、中医证候疗效、心电图疗效,及治疗前后血清TNF-α水平、CRP水平、血脂水平。结果:治疗组患者冠脉再狭窄比例较对照组显著降低,差异具有统计学意义(P<0.05)。治疗组患者LDL-C(低密度脂蛋白胆固醇)、TG(甘油三酯)、TC(总胆固醇)水平显著低于低于对照组(P<0.05),HDL-C(高密度脂蛋白胆固醇)较对照组显著提高,差异具有统计学意义(P<0.05)。治疗组中医证候疗效总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗组心电图疗效总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗组患者TNF-α和CRP水平较对照组显著降低,差异具有统计学意义(P<0.05)。结论:养心通脉汤能有效降低冠脉支架植入术后再狭窄的发生率,改善血脂水平、心电图和中医证候,并降低血清内CRP水平和TNF-α水平。
Objective:To explore the therapeutic effect of Yangxin Guanmai decoction on restenosis in patients undergoing coronary stenting,and to analyze its effect on serum TNF-α(tumor necrosis factor-α)and CRP(C-reactive protein).Methods:Sixty patients who underwent coronary stenting were enrolled.The patients were divided into treatment group(30 cases)and control group(30 cases)by random number table.The control group was treated with aspirin enteric-coated tablets,clopidogrel tablets,and atorvastatin calcium tablets.The treatment group was treated with Yangxin Tongmai decoction on the basis of the treatment of the control group.All patients were treated for 6 months.The proportion of recurrent coronary stenosis,TCM syndrome efficacy,electrocardiogram efficacy,serum TNF-αlevel,CRP level and blood lipid level before and after treatment were counted.Results:The proportion of coronary restenosis in the treatment group was significantly lower than that in the control group and the difference was statistically significant(P<0.05).The levels of LDL-C(low-density lipoprotein cholesterol),TG(triglyceride),and TC(total cholesterol)in the treatment group were significantly lower than those in the control group(P<0.05),HDL-C(high-density lipoprotein cholesterol).The difference was significantly higher than the control group was statistically significant(P<0.05).The total effective rate of TCM syndromes in the treatment group was significantly higher than that in the control group and the difference was statistically significant(P<0.05).The total effective rate of electrocardiogram in the treatment group was significantly higher than that in the control group and the difference was statistically significant(P<0.05).The levels of TNF-αand CRP in the treatment group were significantly lower than those in the control group and the difference was statistically significant(P<0.05).Conclusion:Yangxin Tongmai decoction can effectively reduce the incidence of restenosis after coronary stent implantation,improve blood lipid levels,electrocardiogram and TCM syndrome,and reduce serum CRP levels and TNF-αlevels.
作者
张金李
韩鹏
王曜宇
ZHANG Jinli;HAN Peng;WANG Yaoyu(Department of Laboratory,Kaifeng Central Hospital(Kaifeng475000))
出处
《陕西中医》
2019年第5期572-575,共4页
Shaanxi Journal of Traditional Chinese Medicine
