摘要
肝纤维化是诸多急慢性肝病中的病理过程,指的是肝细胞在发生炎症刺激或坏死时,肝脏内纤维结缔组织发生异常增生的一种病理过程,为肝硬化进展中的早期环节。肝纤维化发生机制复杂,且为动态发展,在肝硬化早期具有可逆性,因此早期诊断肝纤维化是逆转肝硬化的必要前提。目前肝纤维化诊断主要应用病理组织活检作为金标准,但这一方法存在较多不足(有创操作、风险大、局限性)。近年来血清学相关指标检测创伤小、检测速度快、准确率较高,特别是无法实施肝脏穿刺者极为适用于这一检测技术。本文综合国内外报道,对血清学检测的进展进行了归纳和分析。有研究表明,中医药对逆转肝纤维化有较好的疗效,本文对中医药应用于肝纤维化的治疗进展也进行了总结。
Liver fibrosis is a pathological process in many acute and chronic liver diseases. It refers to a pathological process in which hepatic cells have abnormal proliferation of fibrous connective tissue in the presence of inflammatory stimuli or necrosis, which is an early stage in the progression of cirrhosis. The mechanism of liver fibrosis is complex and dynamic, and it is reversible in the early stage of cirrhosis. Therefore, early diagnosis of liver fibrosis is a necessary prerequisite for reversing cirrhosis. At present, the diagnosis of liver fibrosis is mainlybased on pathological biopsy as the gold standard, but this method has many shortcomings(invasive operation, high risk, limitations). In recent years, the detection of serological related indicators is less invasive, faster and more accurate, especially for those who can not perform liver puncture, which is very suitable for this detection technology. In this paper, the progress of serological detection is summarized and analyzed based on domestic and foreign reports. Studies have shown that traditional Chinese medicine has a good effect on reversing liver fibrosis. This paper also summarizes the progress of the application of traditional Chinese medicine in the treatment of liver fibrosis.
作者
吴立兵
申力军
楚金东
刘博
于晓莉
毕茜
WU Li-bing;SHEN Li-jun;CHU Jin-dong(Fifth Medical Center of PLA General Hospital, Beijing 100039, China)
出处
《中国实用医药》
2019年第10期189-191,共3页
China Practical Medicine
基金
北京市科技新星与领军人才培养(项目编号:Z161100004916170)
关键词
肝纤维化
诊断
治疗
血清学检测指标
中成药
Hepatic fibrosis
Diagnosis
Treatment
Serological indicators
Traditional Chinese medicine
作者简介
通讯作者:毕茜.
