摘要
动脉自旋标记灌注成像是一种利用血液中的水质子作为示踪剂的MR成像技术,通过脑血流量(CBF)的定性及定量图,可进行CBF灌注变化对比,具有安全、非侵袭、无辐射、重复性好、成像时间相对较短等优点,且全脑覆盖评估脑功能,可用于灌注成像或血管成像,技术逐渐趋于成熟,被广泛用于脑血管疾病及肿瘤的研究。近年来逐渐被用于研究认知障碍领域,取得一定的进展,就这些新进展及其在认知领域的应用现状予以综述。
Arterial spin labeling perfusion magnetic resonance imaging(MRI) is one of imaging techniques which uses water protons in blood as tracer. Based on the qualitative and quantitative images of cerebral blood flow, arterial spin labeling perfusion MRI can be used for the comparison of the changes in cerebral blood flow perfusion. Besides the advantages of safety, noninvasion, non-radiation, good repeatability and short imaging time, arterial spin labeling perfusion MRI can also achieve wholebrain imaging and assessment of brain functions. Moreover, the technique can be used in perfusion imaging or angiography. With the development of the technique, arterial spin labeling perfusion MRI has been widely used in the study of cerebraovascular disease and tumor. In recent years, the technique has been gradually applied to study cognitive impairment and has made some progress. Herein the progress of arterial spin labeling perfusion MRI in the study of cognitive impairment and its application status are reviewed.
作者
刘晓俊
欧阳樱君
王邵晟
方穗雄
陈志宁
唐梁
陈杰
周进
潘小平
LIU Xiaojun;OUYANG Yingjun;WANG Shaosheng;FANG Suixiong;CHEN Zhining;TANG Liang;CHEN Jie;ZHOU Jin;PAN Xiaoping(Department of Traditional Chinese Medicine, Guangzhou First People's Hospital, Guangzhou 510180, China;Department of Neurology,Guangzhou First People's Hospital, Guangzhou 510180, China;Emergency Department, Guangzhou First People's Hospital, Guangzhou510180, China)
出处
《中国医学物理学杂志》
CSCD
2019年第4期435-439,共5页
Chinese Journal of Medical Physics
基金
广东省科学技术厅-广东省中医药科学院联合专项项目(2017A020213027)
广州市科技计划项目(2016201604030018
2012J5100039)
广东省医学科学技术研究基金(A2016326)
关键词
磁共振成像
灌注成像
动脉自旋标记
认知障碍
综述
magnetic resonance imaging
perfusion imaging
arterial spin labeling
cognitive impairment
review
作者简介
刘晓俊,主任中医师,研究方向:中医脑病,E-mail:alxj@163.com;通信作者:欧阳樱君,主任医师,研究方向:神经内科,E-mial:ougaouyang@163.com;通信作者:潘小平,主任医师,研究方向:神经内科,Emial:panxp@163.com.
