摘要
目的评价盐酸阿比多尔在治疗流行性感冒(流感)诱发慢性阻塞性肺疾病急性加重(AECOPD)中的临床疗效。方法选择2016年4月至2018年4月我院84例因流感而发生AECOPD的患者,随机分为治疗组和对照组,每组42例。各组均按照治疗指南,采用茶碱类药物、抗生素、激素类喷剂、β-受体激动剂等常规药物治疗。治疗组在常规治疗的基础上加用盐酸阿比多尔。连续观察5 d,比较两组的治疗效果以及治疗前后两组的炎症应激指标、血气指标和肺功能指标的差异。结果治疗后,治疗组的显效率(76.19%)明显高于对照组(59.52%),无效率(4.76%)明显低于对照组(7.14%),两组比较差异有统计学意义(P<0.05)。治疗组的炎症指标、血气指标和肺功能指标的改善情况均优于对照组(P<0.05)。结论对于流感诱发的AECOPD患者,在使用常规药物的基础上,加用盐酸阿比多尔,可以取得更好的治疗效果。
Objective To evaluate the efficacy of hydrochloride arbidol for acute exacerbation of chronic obstructive pulmonary disease(AECOPD)induced by influenza.Methods Totally 84 patients diagonsed as AECOPD induced by influenza from April 2016 to April 2018 in our hospital were randomly divided into treatment group and control group,42 cases in each group.The two groups were treated with rountine drugs under the guideline,such as doxofylline,steroids,β-receptor blocker and antibiotics,while hydrochloride arbidol was added to the treatment group.After the continuous observation for 5 days,the efficacy and the indicators of inflammation,blood gas analysis and lung-function of the two groups before and after treatment were compared.Results After treatment,the efficient rate of treatment group was higher than that of control group(76.19% vs.59.52%),while the inefficiency rate of treatment group was lower than that of control group(4.76% vs.7.14%).The improvement of inflammatory factors,indicators of blood gas analysis and lung function in treatment group was better than that in control group(P<0.05).Conclusion For patients with AECOPD induced by influenza,the rountine treatment combined with hydrochloride arbidol is more effective with little side effects,which is worthy of application.
作者
崔玥
韩朗
CUI Yue;HAN Lang(Department of Emergency,Central Hospital of Shenyang Medical College,Shenyang 110024,China;Specialist Clinic of Huaxiang District,Shengjing Hospital of China Medical University,Shenyang 110022,China)
出处
《实用药物与临床》
CAS
2019年第3期270-273,共4页
Practical Pharmacy and Clinical Remedies
关键词
盐酸阿比多尔
慢性阻塞性肺疾病急性加重
流行性感冒
Hydrochloride arbidol
Acute exacerbation of chronic obstructive pulmonary disease
Influenza
