摘要
目的探究急性髓性白血病外周血T淋巴细胞亚群的变化。方法选取2016年4月—2018年4月30例血液科急性髓性白血病患者,作为研究组,选取同期50例体检健康者,作为参照组,所有试验者行T淋巴细胞亚群检测,其中包括外周血CD3^+T淋巴细胞、外周血CD4^+T淋巴细胞、外周血CD8^+T淋巴细胞。回顾分析两组患者的临床资料,对比治疗前、完全缓解者、健康者的CD3^+百分比、CD4^+百分比、CD8^+百分比,以及CD4^+/CD8^+比值,进行统计学分析。结果研究组30例患者在经过系列放疗后,完全缓解共23例。对比参照组与研究组的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比值,研究组明显低于参照组,组间差异有统计学意义(P <0.05)。对比参照组与完全缓解组患者的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比值,组间差异无统计学意义(P> 0.05)。对比研究组与完全缓解组患者的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比值,研究组明显低于完全缓解组,组间差异有统计学意义(P <0.05)。结论急性髓性白血病T淋巴细胞亚群具有明显变化,在经过有效治疗后恢复正常,证明了白血病发生、发展与转归均影响细胞免疫。
Objective To investigate the changes of T lymphocyte subsets in peripheral blood of acute myeloid leukemia.Methods 30 patients with acute myeloid leukemia in the blood department from April 2016 to April 2018 were selected as the study group.50 healthy subjects were selected as the reference group.All the subjects were underwent T lymphocyte subset detection,including Peripheral blood CD3^+T lymphocytes,peripheral blood CD4^+T lymphocytes,peripheral blood CD8+T lymphocytes.The clinical data of the two groups were retrospectively analyzed.The CD3^+percentage,CD4^+percentage,CD8^+percentage,and CD4^+/CD8^+ratio were compared before treatment,complete remission,and healthy people,and statistical analysis was performed.Results In the study group,30 patients underwent a series of radiotherapy,there were 23 cases of complete remission.Compared with the control group and the study group,the CD3^+,CD4^+,CD8^+,CD4^+/CD8^+ratio in the study group was significantly lower than that in the control group,and there was a significant difference between the two groups(P<0.05).There was no significant difference in the ratio of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+between the control group and the complete remission group(P>0.05).The ratio of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+in the study group was significantly lower than that in the complete remission group(P<0.05).Conclusion The T lymphocyte subsets of acute myeloid leukemia have obvious changes and return to normal after effective treatment.It is proved that the occurrence,development and outcome of leukemia affect cellular immunity.
作者
陈荣伴
邹茂权
梁惠如
谭美仲
蔡美霞
CHEN Rongban;ZOU Maoquan;LIANG Huiru;TAN Meizhong;CAI Meixia(Department of Hematology,Jiangmen Central Hospital,Jiangmen Guangdong 529000,China)
出处
《中国卫生标准管理》
2019年第4期36-38,共3页
China Health Standard Management
基金
广东省江门市科技计划项目([2016]98号-016)
作者简介
通信作者:邹茂权.
