摘要
目的回顾性分析慢性肾脏病(CKD)合并肺结核患者的抗结核治疗转归相关因素。方法纳入2017年1月至2021年6月我院收治的资料完整、CKD合并肺结核病患者84例,分析其一般情况、病史特点、化验指标、外周血淋巴细胞亚群、药物不良反应发生率,以及抗结核治疗转归相关因素。结果84例患者中男性占76.54%,中位年龄53.5(41.25,63.00)岁。治疗有效组和无效组患者在性别、年龄、CKD分期、治疗史、吸烟史、糖尿病病史、高血压病史、γ干扰素(interferon-γ,IFN-γ)释放试验、结核抗体、白蛋白、肾功能、尿比重、尿蛋白、尿红细胞等方面比较无统计学差异。治疗无效组血红蛋白、总淋巴细胞计数、CD8^(+)T细胞计数均低于有效组(P<0.05)。Logistic回归分析显示总淋巴细胞计数与治疗转归相关(P<0.05)。结论CKD合并肺结核治疗无效组患者贫血重、CD8^(+)T细胞计数及总淋巴细胞计数减少。总淋巴细胞计数减少与治疗转归差相关。
Objective To retrospectively analyze the factors related to the outcome of anti-tuberculosis treatment in patients with chronic kidney disease(CKD)complicated with pulmonary tuberculosis.MethodsFrom January 2017 to June 2021,84 patients with CKD complicated with pulmonary tuberculosis who were admitted to our hospital with complete data were included.The general conditions,medical history characteristics,laboratory indicators,peripheral blood lymphocyte subsets,incidence of adverse drug reactions,and factors related to the outcome of anti-tuberculosis treatment were analyzed.ResultsAmong the 84 patients,76.54%were male,and the median age was 53.5(41.25,63.00)years.There were no statistical differences between the treatment-effective group and the treatment-ineffective group in the following aspects,including gender,age,stage of CKD,treatment history,smoking history,diabetes history,hypertension history,interferon-gamma release assay,tuberculosis antibody,albumin,renal function,urine specific gravity,urine protein,and urine red blood cells,etc.The hemoglobin,counts of total lymphocytes and CD8^(+)T cells in the treatment-ineffective group were lower than those in the treatment-effective group(P<0.05).Logistic regression analysis showed that the lymphocyte count was associated with the treatment outcome(P<0.05).ConclusionThe treatment-ineffective group showed severe anemia,lower counts of CD8^(+)T cells and total lymphocytes.The lower count of total lymphocytes was associated with the poorer treatment outcome.
作者
俞珊
李志明
段浩凯
杨荔慧
刘银萍
王涛
Shan Yu;Zhiming Li;Haokai Duan;Lihui Yang;Yinping Liu;Tao Wang(Fourth Ward of Department of Tuberculosis,Senior Department of Tuberculosis,Eighth Medical Center of Chinese PLA General Hospital,Beijing 100091,China;Laboratory of Senior Department of Tuberculosis,Eighth Medical Center of Chinese PLA General Hospital,Beijing 100091,China)
出处
《中华肾病研究电子杂志》
2022年第4期207-211,共5页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
关键词
慢性肾脏病
肺结核
淋巴细胞
T细胞亚群
贫血
转归
Chronic kidney disease
Pulmonary tuberculosis
Lymphocyte
T cell subsets
Anemia
Outcome
作者简介
通信作者:王涛,Email:wt19750728@hotmail.com
