摘要
肝癌恶性程度较高,许多癌基因及抑癌基因在肝癌发生发展过程中发挥重要的调控作用。细胞由上皮表型向间质表型转化的过程称为上皮-间质转化(EMT),可以增加肿瘤细胞迁移侵袭能力,长链非编码RNA能够通过多种方式调控EMT过程。综述了EMT相关长链非编码RNA在肝癌中的主要生物学功能以及调控机制的研究进展。
Liver cancer has a high degree of malignancy, and many oncogenes and tumor suppressor genes play an important regulatory role in the development and progression of liver cancer. Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells transform into mesenchymal cells, which can increase the migration and invasion abilities of tumor cells. Long non-coding RNAs (lncRNAs) can regulate EMT process in various ways. This article reviews the research advances in the main biological functions and regulatory mechanisms of EMT-related lncRNAs in liver cancer.
作者
王元
郭涛
李靖华
赵继森
周元龙
杨季红
WANG Yuan;GUO Tao;LI Jinghua(Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第3期656-660,共5页
Journal of Clinical Hepatology
基金
河北省政府资助临床医学优秀人才培养和基础课题研究项目计划(冀财社〔2017〕46号)
作者简介
王元(1990-),男,主要从事肝癌相关lncRNA的功能机制研究;通信作者:杨季红,电子信箱:doctoryangjh@sina.com。
