摘要
目的探讨丁苯酞注射液治疗急性缺血性脑卒中对患者神经功能及认知的影响。方法选取2016-02—2017-11郑州市急救网络医院收治的急性缺血性脑卒中患者106例,按入院顺序分为对照组及研究组各53例。对照组患者进行常规抗血栓及其他对症支持治疗,研究组患者在对照组的基础上联合丁苯酞注射液治疗,2组均连续治疗2周,随访至治疗后3个月。检测并比较2组治疗前后神经功能及认知改善情况。结果研究组神经功能改善总有效率86.79%,显著高于对照组的67.92%(χ~2=5.386,P=0.020);与治疗前比较,治疗后3 d～3个月2组NIHSS评分均呈逐渐降低趋势,MMSE评分及MoCA评分均呈逐渐升高趋势(P<0.01),且治疗后1、3个月研究组NIHSS评分显著低于对照组(P<0.05),治疗后3 d、7 d、1个月及3个月研究组MMSE评分显著高于对照组(P<0.05或0.01);治疗后7 d、1个月及3个月研究组MoCA评分均显著高于对照组(P<0.05或0.01)。治疗期间2组均未见严重不良反应。结论丁苯酞注射液可有效改善急性缺血性脑卒中患者神经功能及认知功能,具有良好的安全性,疗效显著。
Objective To explore the effect of butylphthalide injection on the nerve function and cognition of acute ischemic stroke patients.Methods 106 cases acute ischemic stroke patients treated in First Aid Network Hospital of Zhengzhou City from Feb.2016 to Nov.2017 were selected and divided into control group and study group according to admission order,53 cases were for each group.Patients in control group were treated with conventional antithromboembolism and other symptomatic support treatments,patients in study group were treated with butylphthalide injection on the basis of control group,and were treated for 2 weeks continuously and followed up until 3 month after treatment.The improvement of nerve function and cognition in 2 groups were detected and compared.Results he total effective rate of nerve function improvement in study group was 86.79%,which was higher than that 67.92%in the control group(χ^2=5.386,P=0.020);compared with before treatment,the NIHSS scores from 3 day to 3 month after treatment in 2 groups decreased gradually,the MMSE scores and MoCA scores in 2 groups increased gradually(P<0.01),and the NIHSS scores in study were lower than those in control group 1 month,3 month after treatment(P<0.05),the MMSE scores in study group were higher than those in control group 3 day,7 day,1 month and 3 month after treatment(P<0.05 or P<0.01);the MoCA scores in study group were higher than those in control group 7 day,1 month and 3 month after treatment(P<0.05 or P<0.01).There was no severe adverse reactions occurred during the treatment in 2 groups.Conclusion Butylphthalide injection can improve the nerve function and cognition function of acute ischemic stroke patients effectively,and which has good security.
作者
赵琰
李华
王景涛
ZHAO Yan;LI Hua;WANG Jingtao(Department of Emergency Management,Zhengzhou Emergency Medical Rescue Center,Zhengzhou 450047,China;Department of Emergency,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China;Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2018年第24期2708-2713,共6页
Chinese Journal of Practical Nervous Diseases
基金
河南省中医药科学研究专项(编号:2017ZY2134)
关键词
急性缺血性脑卒中
急性脑梗死
丁苯酞注射液
神经功能
认知
Acute ischemic stroke
Acute cerebral infarction
Butyl phthalate injection
Nerve function
Cognition
作者简介
赵琰,Email:zz120zy@163.com;通信作者:李华,Email:lihua771203@163.com.
