摘要
目的了解内脏利什曼病死亡病例的临床特点及实验室指标变化特征。方法分析北京友谊医院2013年1月—2018年6月4例内脏利什曼病死亡患者的临床资料,比较患者实验室指标的差异。结果 4例内脏利什曼病患者的病程3～12个月,患者均出现了多脏器的损伤,其中3例肝、脾大,2例出现中枢神经系统的损伤。4例患者利什曼原虫IgG抗体为阳性,骨髓涂片中均找到了利杜体。4例患者外周血常规的三系明显降低,清蛋白明显降低,球蛋白升高;4例患者的血清钠离子含量低于135 mmol/L。结论内脏利什曼病患者出现病程长,多脏器损伤,累及中枢神经系统,外周血常规三系显著降低,低蛋白血症,以及低钠血症均提示预后差,病死率高。
Objective To understand the clinical characteristics and changes in laboratory indicators of patients died of visceral leishmaniasis(VL).Methods Clinical data of 4 patients died of VL in Beijing Friendship Hospital from January 2013 to June 2018 were analyzed,differences in laboratory indicators were compared.Results Disease course of 4 cases of VL ranged from 3 to 12 months,all patients had multiple organ damage,including 3 cases with hepatomegaly and splenomegaly,2 cases with central nervous system damage.IgG antibodies of leishmania were positive in 4 patients,Leishman-Donovan body was found in bone marrow smears.Routine peripheral blood test results in 4 patients decreased significantly,albumin decreased significantly and globulin increased;level of serum sodium ion in 4 patients was lower than 135 mmol/L.Conclusion Long disease course,multiple organ damage,involvement of central nervous system,significant reducing in peripheral blood routine test results,hypoproteinemia,and hyponatremia in patients with VL all indicate poor prognosis and high mortality.
作者
李小丽
王非
王磊
郑晓燕
黄敏君
李晶晶
贾永根
邹洋
LI Xiao-li;WANG Fei;WANG Lei;ZHENG Xiao-yan;HUANG Min-jun;LI Jing-jing;JIA Yong-gen;ZOU Yang(Beijing Key Laboratory of Tropical Disease Control and Research, Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2019年第2期115-119,共5页
Chinese Journal of Infection Control
基金
国家自然科学基金(81702018)
北京市卫生系统高层次卫生技术人才培养计划(2015-3-010)
热带病防治研究北京市重点实验室开放课题项目(2017-3-3)
首都医科大学校自然(PYZ2017010)
作者简介
李小丽(1980-),女(汉族),山西省太原市人,主治医师,主要从事热带病及寄生虫病的诊治及其病原体的基础研究;通信作者:邹洋E-mail:zouyang1027@163.com.
