摘要
目的明确黑热病患者的临床特点,为其防治提供依据。方法通过搜索文献数据库,结合本院收治情况,回顾性分析1995年1月-2021年12月湖南省内报告的确诊为黑热病患者的临床特点和流行病学资料。结果共收集到5例黑热病患者,均为散发病例。发病年龄集中在青壮年(>14~60岁,共4例,80%),4例有外出务工或旅行至黑热病流行区域的流行病学史,1例为婴幼儿,为湖南省首例无明确流行病学史的本土病例。主要临床表现和异常的检查结果如下:发热5例(100%),肝脾肿大5例(100%),淋巴结肿大3例(60%);5例患者均出现血细胞下降(100%),2例(40%)死亡,3例救治成功,救治成功患者均是因为及时明确诊断,予患者使用锑剂治疗后痊愈。结论黑热病临床表现多样,对于不明原因发热伴有淋巴结及肝脾肿大、血细胞下降,特别是有北方地区或东南亚地区旅居史的患者应考虑该病可能,避免漏诊和误诊。
Objective To clarify the clinical characteristics of kala-azar patients and provide basis for its prevention and treatment.Methods The clinical characteristics and epidemiological data of kala-azar patients in Hunan province from January 1995 to December 2021 were retrospectively analyzed by searching literature database and combining with the cases diagnosed in our hospital.Results A total of 5 cases of kala-azar were collected,all of which were sporadic cases.The age of onset was mainly young adults(>14-60 years old,4 cases,80%);4 cases had an epidemiological history of working or traveling to the kala-azar endemic area,and 1 case was an infant,which was the first local case with no clear epidemiological history in Hunan province.The main clinical manifestations and abnormal findings were as follows:fever(5 cases,100%),hepatosplenomegaly(5 cases,100%),lymphadenopathy(3 cases,60%);5 patients showed blood cell decline(100%),2 patients(40%)died,and 3 patients were successfully treated.The successful treatment was due to timely diagnosis and antimony treatment.Conclusions The clinical manifestations of kala-azar were diverse.In patients with fever of unknown cause accompanied by lymph node enlargement,hepatosplenomegaly and decreased blood cells,especially those with travel history in northern China or Southeast Asia,the possibility of kala-azar should be considered to avoid missed diagnosis and misdiagnosis.
作者
周扬梅
黄芳
邱芊
刘欣瑜
刘振国
周鹏程
ZHOU Yangmei;HUANG Fang;QIU Qian;LIU Xinyu;LIU Zhenguo;ZHOU Pengcheng(Department of Infectious Diseases,Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China;Gastroenterology Department,Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China;Department of Hospital Infection-Control,Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China)
出处
《热带医学杂志》
CAS
2023年第8期1117-1120,1034,共5页
Journal of Tropical Medicine
基金
湖南省普惠性政策与创新环境建设计划(2021ZK4198)
关键词
黑热病
肝脾肿大
淋巴结肿大
血细胞
Kala-azar
Hepatosplenomegaly
Lymphadenopathy
Blood cells
作者简介
周扬梅(1989-),女,博士,主治医师,研究方向为感染与免疫;通信作者:周鹏程,E-mail:xypcz@csu.edu.cn
