摘要
目的探究单用度洛西汀及联合奥氮平对老年躯体化障碍患者预后的影响。方法选取躯体化障碍老年患者80例为受试对象,根据随机数字表法分为观察组与对照组各40例。对照组患者仅给予度洛西汀治疗,观察组患者则在其基础上联合奥氮平进行治疗。比较治疗前及治疗6周后,两组患者抑郁程度[老年抑郁量表(GDS)]、焦虑程度[老年焦虑量表(GAI)]、生活质量[世界卫生组织生存质量测定简表(WHOQOL-BREF)]变化,分析治疗6周后两组患者治疗效果及6周内药物不良反应发生情况差异。结果治疗6周后,两组患者GDS、GAI评分均较治疗前有显著下降,且观察组明显低于同期对照组(P <0.05);两组患者WHOQOL-BREF评分均较治疗前有显著提升,且观察组明显高于同期对照组(P <0.05);观察组患者治疗有效率明显高于对照组(P <0.05)。治疗6周内,两组患者各项药物不良反应发生率比较差异均无统计学意义(P> 0.05)。结论度洛西汀联合奥氮平治疗老年躯体化障碍较单用度洛西汀效果更为理想,且该方案安全性良好,对疾病预后转归有利。
Objective To explore the effects of duloxetine only and combined with olanzapine on prognosis of elderly patients with somatization disorder.Methods Eighty elderly patients with somatization disorder were selected and divided into the observation group and the control group according to the random number table method,each group had40cases.The control group was treated by duloxetine only,and the observation group was treated by olanzapine on the basis of duloxetine.The depression degree[Geriatric Depression Scale(GDS)],anxiety degree[Geriatric Anxiety Inventory(GAI)]and quality of life[World Health Organization Quality of Life-BREF(WHOQOL-BREF)]were compared between the two groups before treatment and after6weeks of treatment.The therapeutic effects of the two groups after6weeks of treatment and the occurrence of adverse drug reactions within6weeks were analyzed.Results After6weeks of treatment,the scores of GDS and GAI in the two groups were significantly lower than those before treatment,and the scores in the observation group were significantly lower than the control group(P<0.05).The WHOQOL-BREF scores in the two groups were significantly higher than those before treatment,and the score in the observation group was significantly higher than the control group(P<0.05).The treatment effective rate in the observation group was significantly higher than the control group(P<0.05).Within6weeks of treatment,there was no statistically significant difference in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusion Duloxetine combined with olanzapine in the treatment of elderly somatization disorder have more ideal effects than duloxetine only,and the program is safe and beneficial to the prognosis of the disease.
作者
吴莉
郭月平
叶芬
WU Li;GUO Yueping;YE Fen(Guangzhou Civil Affairs Bureau Psychiatric Hospital, Guangzhou 510430, China)
出处
《中国医药科学》
2018年第21期70-73,共4页
China Medicine And Pharmacy
关键词
度洛西汀
奥氮平
老年
躯体化障碍
预后
Duloxetine
Olanzapine
Elderly
Somatization disorder
Prognosis
